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FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression.

作者信息

Liu Man-Hua, Chen Jing, Yang Yun-Sheng, Wang Yin-Qi, Chen Guo-Qiang, Zhang Yu, Huang Ying

机构信息

Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Dept. of Obstetrics-Gynecology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Haematologica. 2021 Mar 1;106(3):903-907. doi: 10.3324/haematol.2020.251462.

DOI:10.3324/haematol.2020.251462
PMID:32354864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7928003/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8d/7928003/cafa20b5fc7a/106903.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8d/7928003/470bfad787f2/106903.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8d/7928003/f3de140f7e58/106903.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8d/7928003/cafa20b5fc7a/106903.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8d/7928003/470bfad787f2/106903.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8d/7928003/f3de140f7e58/106903.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8d/7928003/cafa20b5fc7a/106903.fig3.jpg

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本文引用的文献

1
FAM122A supports the growth of hepatocellular carcinoma cells and its deletion enhances Doxorubicin-induced cytotoxicity.FAM122A 支持肝癌细胞的生长,其缺失可增强多柔比星诱导的细胞毒性。
Exp Cell Res. 2020 Feb 1;387(1):111714. doi: 10.1016/j.yexcr.2019.111714. Epub 2019 Nov 9.
2
CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML.CIP2A 和 SETBP1 介导的 PP2A 抑制作用揭示 AKT S473 磷酸化是 AML 的一个新的生物标志物。
Blood Adv. 2018 May 8;2(9):964-968. doi: 10.1182/bloodadvances.2017013615.
3
Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-Cα by ubiquitin-proteasome system.
miR-15a/16-1 和 miR-15b/16-2 簇通过限制 IL-7 受体表达来调节早期 B 细胞发育。
Front Immunol. 2022 Aug 25;13:967914. doi: 10.3389/fimmu.2022.967914. eCollection 2022.
4
FAM122A Inhibits Erythroid Differentiation through GATA1.FAM122A通过GATA1抑制红细胞分化。
Stem Cell Reports. 2020 Sep 8;15(3):721-734. doi: 10.1016/j.stemcr.2020.07.010. Epub 2020 Aug 6.
鉴定导致 FAM122A 的 SUMO1 修饰物被泛素-蛋白酶体系统降解的 PP2A-Cα。
Biochem Biophys Res Commun. 2018 Jun 7;500(3):676-681. doi: 10.1016/j.bbrc.2018.04.135. Epub 2018 Apr 22.
4
MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia.MYC依赖的RUNX1和GATA2在SET癌基因启动子上的募集增强了急性髓系白血病中PP2A的失活。
Oncotarget. 2016 Jun 6;8(33):53989-54003. doi: 10.18632/oncotarget.9840. eCollection 2017 Aug 15.
5
Protein Kinase Inhibitors as Therapeutic Drugs in AML: Advances and Challenges.蛋白激酶抑制剂作为 AML 的治疗药物:进展与挑战。
Curr Pharm Des. 2017 Nov 16;23(29):4303-4310. doi: 10.2174/1381612823666170703164114.
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FAM122A, a new endogenous inhibitor of protein phosphatase 2A.FAM122A,一种新型蛋白磷酸酶2A内源性抑制剂。
Oncotarget. 2016 Sep 27;7(39):63887-63900. doi: 10.18632/oncotarget.11698.
7
'Acute myeloid leukemia: a comprehensive review and 2016 update'.急性髓系白血病:全面综述及2016年更新
Blood Cancer J. 2016 Jul 1;6(7):e441. doi: 10.1038/bcj.2016.50.
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