去铁胺的高效液相色谱分析。药代动力学和代谢研究。
High-performance liquid chromatographic analysis of desferrioxamine. Pharmacokinetic and metabolic studies.
作者信息
Kruck T P, Teichert-Kuliszewska K, Fisher E, Kalow W, McLachlan D R
机构信息
Department of Physiology and Medicine, University of Toronto, Ontario, Canada.
出版信息
J Chromatogr. 1988 Dec 9;433:207-16. doi: 10.1016/s0378-4347(00)80599-x.
A high-performance liquid chromatographic method has been developed that permits determination and quantitation of desferrioxamine and metabolites as their iron (III) complexes in small samples of mammalian plasma at levels encountered with ion-specific chelation treatments. The technique permits measurement of desferrioxamine and metabolite concentrations which can be used in pharmacokinetic studies. A human study is presented as an example.
已开发出一种高效液相色谱法，该方法能够在离子特异性螯合治疗所涉及的水平下，对小样本哺乳动物血浆中的去铁胺及其代谢产物的铁（III）络合物进行测定和定量。该技术可测量去铁胺和代谢产物的浓度，这些浓度可用于药代动力学研究。本文以一项人体研究为例进行说明。
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