• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population.血管紧张素转换酶插入/缺失（ACE I/D）和血管紧张素原（AGT M235T）多态性与突尼斯人群肥胖风险的关联。
J Renin Angiotensin Aldosterone Syst. 2020 Apr-Jun;21(2):1470320320907820. doi: 10.1177/1470320320907820.
2
Association of angiotensinogen M235T and A(-6)G gene polymorphisms with coronary heart disease with independence of essential hypertension: the PROCAGENE study. Prospective Cardiac Gene.血管紧张素原M235T和A(-6)G基因多态性与冠心病的关联及与原发性高血压的独立性：PROCAGENE研究。前瞻性心脏基因研究
J Am Coll Cardiol. 2001 May;37(6):1536-42. doi: 10.1016/s0735-1097(01)01186-x.
3
Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population.肾素-血管紧张素系统的多态性与普通成年人群的超重和肥胖无关。
Arch Endocrinol Metab. 2019 Jul 29;63(4):402-410. doi: 10.20945/2359-3997000000155.
4
Association of AGT M235T and ACE I/D polymorphisms with the risk of ischemic stroke: meta-analysis in Han Chinese population.AGT M235T 和 ACE I/D 多态性与缺血性脑卒中风险的关联：汉族人群的荟萃分析。
J Neurol Sci. 2012 Sep 15;320(1-2):79-84. doi: 10.1016/j.jns.2012.06.022. Epub 2012 Jul 15.
5
Renin-angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population.肾素-血管紧张素系统多态性与突尼斯人群的高血压状况和肥胖的关系。
Mol Biol Rep. 2012 Apr;39(4):4059-65. doi: 10.1007/s11033-011-1187-2. Epub 2011 Jul 21.
6
Gene polymorphisms of angiotensin-converting enzyme and angiotensinogen and risk of idiopathic ischemic stroke.血管紧张素转换酶和血管紧张素原基因多态性与特发性缺血性脑卒中的风险。
Gene. 2019 Mar 10;688:163-170. doi: 10.1016/j.gene.2018.11.080. Epub 2018 Dec 4.
7
[The effect of the angiotensinogen M235T and the angiotensin-converting enzyme I/D polymorphisms on arterial hypertension and other cardiovascular risk factors].血管紧张素原M235T及血管紧张素转换酶I/D基因多态性对动脉高血压及其他心血管危险因素的影响
Med Clin (Barc). 1999 Jul 10;113(5):164-8.
8
Polymorphisms of the insertion / deletion ACE and M235T AGT genes and hypertension: surprising new findings and meta-analysis of data.插入/缺失血管紧张素转换酶（ACE）基因和M235T血管紧张素原（AGT）基因多态性与高血压：惊人的新发现及数据的荟萃分析
BMC Nephrol. 2005 Jan 11;6:1. doi: 10.1186/1471-2369-6-1.
9
Association between ACE and AGT polymorphism and cardiovascular risk in acromegalic patients.ACE 和 AGT 多态性与肢端肥大症患者心血管风险的关联。
Pituitary. 2017 Oct;20(5):569-577. doi: 10.1007/s11102-017-0819-5.
10
Adipose angiotensinogen secretion, blood pressure, and AGT M235T polymorphism in obese patients.肥胖患者的脂肪组织血管紧张素原分泌、血压及AGT M235T基因多态性
Obes Res. 2004 Mar;12(3):556-61. doi: 10.1038/oby.2004.63.

引用本文的文献

1
Associations between selected genetic variants and lipid profile variability in response to statins in Alzheimer's disease: a prospective observational study.阿尔茨海默病中特定基因变异与他汀类药物治疗反应中血脂谱变异性的关联：一项前瞻性观察研究。
Sao Paulo Med J. 2025 Aug 15;143(4):e2024160. doi: 10.1590/1516-3180.2024.0160.27112024. eCollection 2025.
2
Spectrum of AGT (M235T) rs699 and AGTR1 (A1166C) rs5186 gene variants and its association with coronary artery disease in Pakistani patients.巴基斯坦患者中血管紧张素原（AGT，M235T）rs699和血管紧张素Ⅱ受体1型（AGTR1，A1166C）rs5186基因变异谱及其与冠状动脉疾病的关联
Pak J Med Sci. 2025 Apr;41(4):1151-1156. doi: 10.12669/pjms.41.4.9993.
3
Influence of Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene on Adiposity and Cardiac Function in Patients with Heart Failure.血管紧张素转换酶基因插入/缺失多态性对心力衰竭患者肥胖及心功能的影响
Arq Bras Cardiol. 2025 Jan;122(1):e20240204. doi: 10.36660/abc.20240204.
4
Associations of ACE I/D and AGTR1 rs5182 polymorphisms with diabetes and their effects on lipids in an elderly Chinese population.ACE I/D 和 AGTR1 rs5182 多态性与老年中国人群糖尿病的关联及其对血脂的影响。
Lipids Health Dis. 2024 Jul 30;23(1):231. doi: 10.1186/s12944-024-02222-w.
5
Genetic Polymorphism in Angiotensinogen and Its Association with Cardiometabolic Diseases.血管紧张素原的基因多态性及其与心血管代谢疾病的关联。
Metabolites. 2022 Dec 19;12(12):1291. doi: 10.3390/metabo12121291.
6
Strong Association of Angiotensin Converting Enzyme-2 Gene Insertion/Deletion Polymorphism with Susceptibility to SARS-CoV-2, Hypertension, Coronary Artery Disease and COVID-19 Disease Mortality.血管紧张素转换酶2基因插入/缺失多态性与对严重急性呼吸综合征冠状病毒2的易感性、高血压、冠状动脉疾病及2019冠状病毒病死亡率的强关联
J Pers Med. 2021 Oct 27;11(11):1098. doi: 10.3390/jpm11111098.
7
Relationship between rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population.rs2493132 多态性与中国汉族非酒精性脂肪性肝病患者冠心病风险的关系。
J Int Med Res. 2021 Jul;49(7):3000605211019263. doi: 10.1177/03000605211019263.
8
Genetic polymorphisms associated with obesity in the Arab world: a systematic review.与阿拉伯世界肥胖相关的遗传多态性：系统评价。
Int J Obes (Lond). 2021 Sep;45(9):1899-1913. doi: 10.1038/s41366-021-00867-6. Epub 2021 Jun 15.

本文引用的文献

1
Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population.肾素-血管紧张素系统的多态性与普通成年人群的超重和肥胖无关。
Arch Endocrinol Metab. 2019 Jul 29;63(4):402-410. doi: 10.20945/2359-3997000000155.
2
M235T polymorphism in the angiotensinogen gene and cardiovascular disease: An updated meta-analysis of 39 case-control comparisons.血管紧张素原基因M235T多态性与心血管疾病：39项病例对照比较的最新荟萃分析。
Anatol J Cardiol. 2019 Mar;21(4):222-232. doi: 10.14744/AnatolJCardiol.2019.75282.
3
Effects of angiotensin converting enzyme gene polymorphism on hypertension in Africa: A meta-analysis and systematic review.血管紧张素转化酶基因多态性对非洲高血压的影响：Meta 分析和系统评价。
PLoS One. 2019 Feb 14;14(2):e0211054. doi: 10.1371/journal.pone.0211054. eCollection 2019.
4
Gene polymorphisms of angiotensin-converting enzyme and angiotensinogen and risk of idiopathic ischemic stroke.血管紧张素转换酶和血管紧张素原基因多态性与特发性缺血性脑卒中的风险。
Gene. 2019 Mar 10;688:163-170. doi: 10.1016/j.gene.2018.11.080. Epub 2018 Dec 4.
5
The relationship between ACE/AGT gene polymorphisms and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes.中国2型糖尿病患者中ACE/AGT基因多态性与糖尿病视网膜病变风险的关系
J Renin Angiotensin Aldosterone Syst. 2018 Jan-Mar;19(1):1470320317752955. doi: 10.1177/1470320317752955.
6
Implications of ACE (I/D) Gene Variants to the Genetic Susceptibility of Coronary Artery Disease in Asian Indians.血管紧张素转换酶（I/D）基因变异对亚洲印度人冠状动脉疾病遗传易感性的影响。
Indian J Clin Biochem. 2017 Jun;32(2):163-170. doi: 10.1007/s12291-016-0588-3. Epub 2016 Jul 13.
7
ACE Gene I/D Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes Mellitus.1574例2型糖尿病患者的ACE基因I/D多态性与肥胖
Dis Markers. 2016;2016:7420540. doi: 10.1155/2016/7420540. Epub 2016 Dec 26.
8
Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study.血管紧张素转换酶插入/缺失多态性与埃及女性肥胖及一些相关疾病的关联：一项病例对照观察研究
Nutr Metab (Lond). 2016 Oct 12;13:68. doi: 10.1186/s12986-016-0127-5. eCollection 2016.
9
Association of obesity with hypertension and dyslipidemia in type 2 diabetes mellitus subjects.2型糖尿病患者中肥胖与高血压和血脂异常的关联。
Diabetes Metab Syndr. 2017 Jan-Mar;11(1):37-41. doi: 10.1016/j.dsx.2016.07.004. Epub 2016 Jul 21.
10
Case-control association study of polymorphisms in the angiotensinogen and angiotensin-converting enzyme genes and coronary artery disease and systemic artery hypertension in African-Brazilians and Caucasian-Brazilians.血管紧张素原和血管紧张素转换酶基因多态性与非洲裔巴西人和高加索裔巴西人冠状动脉疾病及系统性动脉高血压的病例对照关联研究。
J Genet. 2016 Mar;95(1):63-9. doi: 10.1007/s12041-015-0599-5.

血管紧张素转换酶插入/缺失（ACE I/D）和血管紧张素原（AGT M235T）多态性与突尼斯人群肥胖风险的关联。

Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population.

机构信息

Biochemistry Laboratory, LR12ES05 "Nutrition-Functional Foods and Vascular Health", Faculty of Medicine, University of Monastir, Tunisia.

Department of Internal Medicine, CHU F. Bourguiba, Tunisia.

出版信息

J Renin Angiotensin Aldosterone Syst. 2020 Apr-Jun;21(2):1470320320907820. doi: 10.1177/1470320320907820.

DOI:10.1177/1470320320907820
PMID:32356512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7227147/
Abstract

OBJECTIVE

This study aims to determine whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and body mass index (BMI) in a Tunisian population.

METHODS

We designed an age- and sex-matched case-control study. The height and weight were measured and BMI was calculated. A total of 259 overweight-obese patients and 369 healthy controls were genotyped for the ACE I/D and AGT M235T genes using polymerase chain reaction and restriction fragment length polymorphism.

RESULTS

ACE I/D and AGT M235T genes were associated with BMI, waist circumference and overweight-obesity (p⩽0.001). In an additive model, the I and the M alleles in ACE and AGT variants, respectively, were associated with a lower BMI: -1.45 and -2.29 units, respectively. ACE I/D genotypes were associated with dyslipidemia; AGT M235T genotypes with dyslipidemia and total cholesterol.

CONCLUSION

These data suggest that variations in ACE I/D and AGT M235T affect the risk of overweight-obesity, BMI and dyslipidemia, and could point to a key molecular pathway of metabolic syndrome and its related comorbidities.

摘要

目的

本研究旨在探讨 ACE I/D 和 AGT M235T 基因多态性与超重肥胖及体重指数（BMI）在突尼斯人群中的相关性。

方法

我们设计了一项年龄和性别匹配的病例对照研究。测量身高和体重，并计算 BMI。共对 259 名超重肥胖患者和 369 名健康对照者进行 ACE I/D 和 AGT M235T 基因的聚合酶链反应和限制性片段长度多态性检测。

结果

ACE I/D 和 AGT M235T 基因与 BMI、腰围和超重肥胖相关（p ⩽ 0.001）。在加性模型中，ACE 和 AGT 变异体中的 I 和 M 等位基因分别与较低的 BMI 相关：分别为-1.45 和-2.29 个单位。ACE I/D 基因型与血脂异常相关；AGT M235T 基因型与血脂异常和总胆固醇相关。

结论

这些数据表明，ACE I/D 和 AGT M235T 的变异影响超重肥胖、BMI 和血脂异常的风险，可能指出代谢综合征及其相关并发症的关键分子途径。