Kravtsov G M, Dulin N O, Postnov Y V
Central Research Laboratory, Ministry of Public Health, Moscow, USSR.
J Hypertens. 1988 Nov;6(11):853-7. doi: 10.1097/00004872-198811000-00002.
The activity of protein kinase C and A was studied in the erythrocytes of patients with essential hypertension (EH) and in spontaneously hypertensive rats (SHR, Okamoto-Aoki strain). Protein kinase C activity was also studied in the erythrocytes of patients with hypertension of renal origin. Protein kinase C activity in the lysate of erythrocytes of patients with EH and in SHR was found to be increased 1.6-2.0-fold as compared to that in normotensive controls. No notable differences in protein kinase A activity were observed between hypertensive and normotensive groups. In erythrocytes of patients with renal hypertension, no notable changes in protein kinase C activity were revealed.
对原发性高血压（EH）患者及自发性高血压大鼠（SHR，冈本-青木品系）红细胞中的蛋白激酶C和A活性进行了研究。还对肾源性高血压患者的红细胞中的蛋白激酶C活性进行了研究。结果发现，与血压正常的对照组相比，EH患者及SHR红细胞裂解物中的蛋白激酶C活性增加了1.6至2.0倍。高血压组和血压正常组之间未观察到蛋白激酶A活性有显著差异。在肾性高血压患者的红细胞中，未发现蛋白激酶C活性有显著变化。
