Animal Pathology Laboratory, Santa Catarina State University, Av. Luís de Camões, Conta Dinheiro, Lages, Brazil.
Mycology Section, Faculty of Veterinary, Federal University of Rio Grande do Sul, Agronomia, Porto Alegre, Brazil.
J Comp Pathol. 2020 Apr;176:165-169. doi: 10.1016/j.jcpa.2020.03.005. Epub 2020 Apr 15.
This report describes a case of tracheobronchitis caused by Aspergillus fumigatus in a cow. A 4-year-old Jersey cow was submitted for necropsy examination. Grossly, the mucosa of the trachea and bronchi was diffusely reddened and was covered by a moderate amount of yellow, caseous material, sometimes with small foci of grey 'cotton-like' appearance, suggestive of filamentous fungus. Microscopical analysis of the trachea and bronchi showed marked diffuse mucosal and submucosal necrosis with a large amount of cellular debris, fibrinous exudation and inflammatory infiltration dominated by macrophages and neutrophils. There were large numbers of septate fungal hyphae with acute bifurcation angles and conidia and vesicles typical of Aspergillus spp. that were stained by the Grocott method. A. fumigatus growth in mycological culture from the trachea and bronchi was confirmed by molecular identification. Tracheobronchitis caused by A. fumigatus infection in cattle is poorly described and requires further research to improve the therapeutic management of the disorder.
本报告描述了一例由烟曲霉引起的奶牛气管支气管炎。送检一头 4 岁的泽西奶牛进行剖检检查。大体检查可见，气管和支气管的黏膜弥漫性发红，被中等量的黄色、干酪样物质覆盖，有时可见小的灰色“棉花状”病灶，提示为丝状真菌。气管和支气管的显微镜分析显示，黏膜和黏膜下组织有明显的弥漫性坏死，有大量细胞碎片、纤维渗出物和以巨噬细胞和中性粒细胞为主的炎症浸润。有大量分隔的真菌菌丝，急性分支角和分生孢子和囊泡典型的曲霉属。经 Grocott 法染色证实，从气管和支气管的真菌培养物中分离出烟曲霉。由烟曲霉感染引起的牛气管支气管炎描述甚少，需要进一步研究以改善该疾病的治疗管理。
