Erasmus MC University Medical Center Rotterdam, Department of Gastroenterology and Hepatology, Erasmus Medical Center, Gravendijkwal 230, 3015CE, Rotterdam, the Netherlands.
Best Pract Res Clin Gastroenterol. 2020 Feb-Apr;44-45:101671. doi: 10.1016/j.bpg.2020.101671. Epub 2020 Mar 6.
Hormonal changes during pregnancy instigate numerous physiological changes aimed at the growth and delivery of a healthy baby. A careful balance between immunological tolerance against fetal antigens and immunity against infectious agents needs to be maintained. A three-way interaction between pregnancy hormones, the immune system and our microbiota is now emerging. Recent evidence suggests that microbial alterations seen during pregnancy may help maintain homeostasis and aid the required physiological changes occurring in pregnancy. However, these same immunological and microbial alterations may also make women more vulnerable during pregnancy and the post-partum period, especially regarding immunological and infectious diseases. Thus, a further understanding of the host-microbial interactions taking place during pregnancy may improve identification of populations at risk for adverse pregnancy outcomes.
妊娠期间的激素变化会引发许多生理变化，旨在促进健康婴儿的生长和分娩。需要在针对胎儿抗原的免疫耐受和针对感染性病原体的免疫之间保持谨慎的平衡。妊娠激素、免疫系统和我们的微生物组之间的三向相互作用正在出现。最近的证据表明，妊娠期间观察到的微生物变化可能有助于维持体内平衡并辅助妊娠期间发生的所需生理变化。然而，这些相同的免疫和微生物变化也可能使女性在妊娠和产后期间更加脆弱，尤其是在免疫和传染病方面。因此，进一步了解妊娠期间发生的宿主-微生物相互作用可能有助于识别有不良妊娠结局风险的人群。
