Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, PR China; School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing, 100029, PR China.
Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, PR China.
J Ethnopharmacol. 2021 Jan 10;264:112915. doi: 10.1016/j.jep.2020.112915. Epub 2020 Apr 28.
The genus Stellera Linn. consists of species of perennial herbs and shrubs, and is mainly distributed in the temperate regions of east Asia to west Asia. There are 10∼12 species in the world, two species in China: Stellera chamaejasme Linn. and Stellera formosana Hayata ex Li. As recorded, the roots of Stellera species are used to dissipate phlegm and relieve pain. The roots and the barks can be used for papermaking.
This review aims to summarize the ethnopharmacological uses, chemical constituents, pharmacological activities, clinical applications and toxicology of the genus Stellera to better understand their therapeutic potential in the future.
The relevant information of the genus Stellera was collected from scientific databases (Pubmed, ACS website, SciFinder Scholar, Elsevier, Google Scholar, Web of Science and CNKI). Information was also gathered from 'Flora Republicae Popularis Sinicae (〈〈〉〉)', folk records, conference papers on ethnopharmacology, Ph.D. and Masters' Dissertation.
Stellera plants have been studied as traditional folk medicines all around the world. The chemical constituents of Stellera species mainly comprise terpenoids, flavonoids, coumarins, lignans, and so on. Extracts and compounds of Stellera species exhibit extensive pharmacological activities, such as anti-tumor, anti-viral, anti-convulsive, anti-epileptic, anti-bacterial and anti-insect activities, etc. Clinical applications have suggested that the genus Stellera has the effects in treating several skin diseases and cancers, however, the results should be further verification. The genus Stellera plants are toxic and should be used reasonable.
This paper reviewed the ethnopharmacological uses, chemical constituents, pharmacology, clinical applications and toxicology of the genus Stellera. The genus Stellera has broad application prospects. However, further in-depth studies are needed to determine the medical uses of the genus and its chemical constituents, pharmacological activities, clinical applications and toxicology.
莨菪属植物由多年生草本和灌木组成，主要分布于东亚至西亚的温带地区。全世界有 10∼12 种，中国有 2 种：莨菪莨菪和台湾莨菪。据记载，莨菪属植物的根用于化痰止痛。根和树皮可用于造纸。
本综述旨在总结莨菪属植物的民族药理学用途、化学成分、药理学活性、临床应用和毒理学，以期更好地了解其未来的治疗潜力。
从科学数据库（Pubmed、ACS 网站、SciFinder Scholar、Elsevier、Google Scholar、Web of Science 和中国知网）中收集了莨菪属植物的相关信息。还从《中国植物志》、民间记录、民族药理学会议论文、博士和硕士论文中收集了信息。
莨菪属植物已被世界各地用作传统民间药物。莨菪属植物的化学成分主要包括萜类、黄酮类、香豆素类、木脂素类等。莨菪属植物的提取物和化合物表现出广泛的药理活性，如抗肿瘤、抗病毒、抗惊厥、抗癫痫、抗菌和抗昆虫活性等。临床应用表明，莨菪属植物具有治疗多种皮肤病和癌症的功效，但结果尚需进一步验证。莨菪属植物有毒，应合理使用。
本文综述了莨菪属植物的民族药理学用途、化学成分、药理学、临床应用和毒理学。莨菪属植物具有广阔的应用前景。然而，需要进一步深入研究，以确定该属植物及其化学成分、药理学活性、临床应用和毒理学的药用价值。
