Ruangrungsi N, Likhitwitayawuid K, Kasiwong S, Lange G L, Decicco C P
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
J Nat Prod. 1988 Nov-Dec;51(6):1220-5. doi: 10.1021/np50060a027.
Six components have been isolated from the bark of Michelia rajaniana, and their structures have been determined by spectroscopic analysis. Four of the components have been reported previously: The germacranolide (-)-parthenolide and the oxoaporphinoid alkaloid liriodenine have been observed as constituents of several species, and (-)-bisparthenolidine and (+)-paramicholide have been reported recently by us as constituents of Paramichelia baillonii. The two new components 3 and 4, which are novel derivatives of parthenolide and contain an unusual N-acetyl substituent at C-13, have been given the names (+)-N-acetylparthenolidine and (+)-N-acetyl-8 alpha-hydroxyparthenolidine, respectively. The crude CHCl3 extract of the bark of M. rajaniana exhibited strong cytotoxicity in the KB cell culture assay.
从南亚含笑的树皮中分离出了六种成分，并通过光谱分析确定了它们的结构。其中四种成分此前已有报道：吉马烷型倍半萜内酯（-）-小白菊内酯和氧代阿朴菲生物碱鹅掌楸碱已在多个物种中被观察到，作为成分存在，并且（-）-双小白菊内酯和（+）-对米氏内酯最近已被我们报道为滇南含笑的成分。两种新成分3和4，它们是小白菊内酯的新型衍生物，且在C-13处含有一个不寻常的N-乙酰基取代基，分别被命名为（+）-N-乙酰基小白菊内酯和（+）-N-乙酰基-8α-羟基小白菊内酯。南亚含笑树皮的氯仿粗提取物在KB细胞培养试验中表现出很强的细胞毒性。
