一种光化学方法用于 18-降-17β-羟甲基-17α-甲基雄甾-13-烯甾体。
A photochemical approach to 18-nor-17β-hydroxymethyl-17α-methylandrost-13-ene steroids.
机构信息
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich st., 5/2, 220141 Minsk, Belarus.
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich st., 5/2, 220141 Minsk, Belarus.
出版信息
Steroids. 2020 Jul;159:108652. doi: 10.1016/j.steroids.2020.108652. Epub 2020 Apr 28.
A photochemical approach to 18-nor-17β-hydroxymethyl-17α-methylandrost-13-ene unit of the long-term metabolites of 17-methylated androgenic anabolic steroids (AAS) is reported. It is based on a visible light-promoted radical decarboxylative alkynylation of steroidal redox-active ester. The developed method was used in synthesis of the long-term metabolite of AAS oxymesterone.
本文报道了一种光化学方法，用于合成 17-甲基雄激素同化类固醇（AAS）的长期代谢物中的 18-去甲-17β-羟甲基-17α-甲基雄甾-13-烯单元。该方法基于可见光促进的甾体氧化还原活性酯的自由基脱羧炔基化反应。所开发的方法用于合成 AAS 氧甲睾酮的长期代谢物。
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