Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS) and Hospital Clínico Universitario and Universidade de Santiago de Compostela (SERGAS), Travesa da Choupana s/n 15706 Galicia, Spain; Laboratorio de Inmunología, Servicio de Análisis Clínicos, Hospital Clínico Universitario Santiago de Compostela (SERGAS), Travesa da Choupana s/n 15706 Galicia, Spain.
Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS) and Hospital Clínico Universitario and Universidade de Santiago de Compostela (SERGAS), Travesa da Choupana s/n 15706 Galicia, Spain; Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Travesa da Choupana s/n 15706 Galicia, Spain.
J Infect. 2020 Aug;81(2):183-189. doi: 10.1016/j.jinf.2020.04.041. Epub 2020 Apr 30.
Rotavirus, a major etiological agent of acute diarrhea in children worldwide, has historically been linked to autoimmunity. In the last few years, several physiopathological approaches have been proposed to explain the leading mechanism triggering autoimmunity, from the old concept of molecular mimicry to the emerging theory of bystander activation and break of tolerance. Epidemiological and immunological data indicate a strong link between rotavirus infection and two of the autoimmune pathologies with the highest incidence: celiac disease and diabetes. The role for current oral rotavirus vaccines is now being elucidated, with a so far positive protective association demonstrated.
轮状病毒是全球儿童急性腹泻的主要病因之一，与自身免疫有关。在过去的几年中，已经提出了几种病理生理学方法来解释引发自身免疫的主要机制，从旧的分子模拟概念到新兴的旁观者激活和耐受破坏理论。流行病学和免疫学数据表明，轮状病毒感染与两种发病率最高的自身免疫性疾病之间存在很强的联系：乳糜泻和糖尿病。目前正在阐明口服轮状病毒疫苗的作用，目前已证明具有积极的保护相关性。
