Erasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam , Rotterdam, The Netherlands.
J Psychoactive Drugs. 2020 Sep-Oct;52(4):300-308. doi: 10.1080/02791072.2020.1761573. Epub 2020 May 2.
Psychedelic substances are currently experiencing a renaissance in interest for both therapeutic as well as recreational applications. It has been proposed that microdosing, i.e., ingesting sub-perceptual doses of a psychedelic, could confer some of the benefits of these substances to users while minimizing the risks associated with full-dose use. This review aimed to summarize and examine the extant literature on psychedelic microdosing. Exploratory evidence published to date indicates a variety of benefits reported by microdosers including improvements in mood, focus, and creativity, with some null reports, and a minority of people reporting selective negative consequences such as increased anxiety and physiological discomfort. Methodological limitations of current evidence, however, make definitive conclusions hard to draw. Recommendations for future research are given.
迷幻物质目前在治疗和娱乐应用方面的兴趣正在复兴。有人提出，微剂量摄入，即摄入低于感知的迷幻药物剂量，可能会为使用者带来这些物质的一些益处，同时将与全剂量使用相关的风险降至最低。本综述旨在总结和检查目前关于迷幻药物微剂量使用的文献。迄今为止发表的探索性证据表明，微剂量使用者报告了各种益处，包括改善情绪、注意力和创造力，也有一些无效报告，少数人报告了选择性的负面后果，如增加焦虑和生理不适。然而，目前证据的方法学限制使得难以得出明确的结论。给出了对未来研究的建议。
