Hughson A V, Cooper A F, McArdle C S, Smith D C
University Department of Psychological Medicine, Glasgow, U.K.
J Psychosom Res. 1988;32(4-5):393-402. doi: 10.1016/0022-3999(88)90022-0.
The performance of the General Health Questionnaire as a case detector was assessed in 75 patients receiving chemotherapy for early breast cancer. The questionnaire and its subscales were found to be valid when compared with observer ratings. The misclassification rate of the 60-item version of the questionnaire was lowest when the standard threshold score for clinical morbidity was doubled to 24. It was lowest for the 28-item version when the threshold score was doubled to 10. Suggested threshold scores for clinical morbidity for the subscales are: anxiety and insomnia subscale 6/7; severe depression subscale 2/3; somatic symptoms subscale 6/7; and social dysfunction subscale 7/8. However, lower thresholds would be appropriate if the questionnaire were used as screening instrument prior to interview by a trained observer.
在75例接受早期乳腺癌化疗的患者中，对一般健康问卷作为病例检测工具的性能进行了评估。与观察者评分相比，该问卷及其分量表被发现是有效的。当临床发病率的标准阈值分数翻倍至24分时，60项版本问卷的误分类率最低。当阈值分数翻倍至10分时，28项版本问卷的误分类率最低。分量表临床发病率的建议阈值分数为：焦虑和失眠分量表6/7；重度抑郁分量表2/3；躯体症状分量表6/7；以及社会功能障碍分量表7/8。然而，如果该问卷在由训练有素的观察者进行访谈之前用作筛查工具，则较低的阈值将是合适的。
