Hughson A V, Cooper A F, McArdle C S, Smith D C
University Department of Psychological Medicine, Glasgow, U.K.
J Psychosom Res. 1988;32(4-5):383-91. doi: 10.1016/0022-3999(88)90021-9.
Psychosocial morbidity was examined in 90 consecutive patients with Stage I or II breast cancer aged under 70 treated by mastectomy. In the two years after surgery, the prevalences of depression and anxiety of clinical degree were generally under 10%--less than half of those reported in early controlled studies in the United Kingdom. However, cancer patients aged under 50 showed significantly higher prevalences compared with cancer patients aged 50 or above and compared with matched control subjects with benign breast disease. Social and work problems were common at all ages. Sexual problems were more severe than mood disturbance. Patients at risk of mood disturbance could be predicted by a combination of age, measures of emotional lability and whether or not they were receiving chemotherapy. The results of this study are consistent with those of other recent reports from the United Kingdom and United States, which show that following mastectomy, mood disturbance of clinical degree may be considerably less common than has previously been supposed.
对90例年龄在70岁以下、接受乳房切除术治疗的I期或II期乳腺癌患者的心理社会发病率进行了研究。在术后两年，临床程度的抑郁和焦虑患病率总体低于10%——不到英国早期对照研究报告患病率的一半。然而，与50岁及以上的癌症患者以及匹配的良性乳腺疾病对照受试者相比，50岁以下的癌症患者患病率显著更高。社会和工作问题在各年龄段都很常见。性问题比情绪障碍更严重。通过年龄、情绪不稳定程度的测量以及是否接受化疗的综合因素可以预测有情绪障碍风险的患者。本研究结果与英国和美国近期的其他报告一致，这些报告表明，乳房切除术后，临床程度的情绪障碍可能比以前认为的要少见得多。
