Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
J Mater Chem B. 2020 May 27;8(20):4469-4474. doi: 10.1039/d0tb00083c.
Convenient strategies to transform regular liposomes or nano-micelles into multifunctional theranostics would be highly valuable in cancer therapy. Herein, we developed an amphiphilic fluorinated porphyrin dendrimer as a multifunctional "add-on" module which would self-assemble onto liposomal drug delivery systems and conveniently transform the liposomes into novel theranostics. Through cancer cells and murine xenograft tumor model assays, the theranostics showed valuable fluorescence/19F magnetic resonance dual modal imaging and highly efficient chemo-photodynamic therapy. The modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics.
将常规脂质体或纳米胶束转化为多功能治疗药物的便捷策略在癌症治疗中具有重要的应用价值。在此，我们开发了一种两亲性氟代卟啉树状大分子作为多功能“附加”模块，它可以自组装到脂质体药物传递系统上，并将脂质体方便地转化为新型治疗药物。通过癌细胞和小鼠异种移植肿瘤模型实验，该治疗药物显示出有价值的荧光/19F 磁共振双模成像和高效的化学-光动力治疗效果。这种模块化策略促进了多功能治疗药物的便捷和标准化制备。
