Rodríguez-Cerdeira Carmen, Martínez-Herrera Erick, Fabbrocini Gabriella, Sanchez-Blanco Beatriz, López-Barcenas Adriana, El-Samahy May, Juárez-Durán Eder R, González-Cespón José Luís
Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, 36213 Vigo, Spain.
Dermatology Department, Hospital do Vithas Ntra. Sra. de Fatima, 36206 Vigo, Spain.
J Fungi (Basel). 2021 Nov 29;7(12):1025. doi: 10.3390/jof7121025.
The most important aetiological agent of opportunistic mycoses worldwide is spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of occur with greater frequency and variable resistance patterns. Photodynamic therapy (PDT) has been recognised as an alternative treatment to kill pathogenic microorganisms. PDT utilises a photosensitizer, which is activated at a specific wavelength and oxygen concentration. Their reaction yields reactive oxygen species that kill the infectious microorganism. A systematic review of new applications of PDT in the management of candidiasis was performed. Of the 222 studies selected for in-depth screening, 84 were included in this study. All the studies reported the antifungal effectiveness, toxicity and dosimetry of treatment with antimicrobial PDT (aPDT) with different photosensitizers against spp. The manuscripts that are discussed reveal the breadth of the new applications of aPDT against spp., which are resistant to common antifungals. aPDT has superior performance compared to conventional antifungal therapies. With further studies, aPDT should prove valuable in daily clinical practice.
全球范围内机会性真菌病最重要的病原体是白色念珠菌属。这些酵母菌可在宿主体内引起严重感染，可能是致命的。白色念珠菌属的分离株出现频率更高且耐药模式多样。光动力疗法（PDT）已被公认为一种杀灭致病微生物的替代治疗方法。PDT利用一种光敏剂，该光敏剂在特定波长和氧浓度下被激活。它们的反应产生活性氧，从而杀死感染性微生物。对PDT在念珠菌病管理中的新应用进行了系统综述。在选择进行深入筛选的222项研究中，本研究纳入了84项。所有研究都报告了使用不同光敏剂的抗菌光动力疗法（aPDT）治疗白色念珠菌属的抗真菌有效性、毒性和剂量测定。所讨论的手稿揭示了aPDT针对对常见抗真菌药物耐药的白色念珠菌属的新应用范围。与传统抗真菌疗法相比，aPDT具有更优的性能。随着进一步研究，aPDT在日常临床实践中应会被证明具有价值。
