Liverpool School of Tropical Medicine, Institute of Infection and Global Health University of Liverpool, UK.
Department of Critical Care Medicine, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.
Anaesthesia. 2020 Jul;75(7):896-903. doi: 10.1111/anae.15040. Epub 2020 May 4.
Critical care survivors suffer persistent morbidity and increased risk of mortality as compared with the general population. Nevertheless, there are no standardised tools to identify at-risk patients. Our aim was to establish whether the Sabadell score, a simple tool applied by the treating clinician upon critical care discharge, was independently associated with 5-year mortality through a prospective observational cohort study of adults admitted to a general critical care unit. The Sabadell score, which is a measure of clinician-assigned survival perception, was applied to all patients from September 2011 to December 2017. The primary outcome was 5-year mortality, assessed using a multivariable flexible parametric survival analysis adjusted for baseline characteristics and clinically relevant covariates. We studied 5954 patients with a minimum of 18 months follow-up. Mean (SD) age was 59.5 (17.0) years and 3397 (57.1%) patients were men. We categorised 2287 (38.4%) patients as Sadabell 0; 2854 (47.9%) as Sadabell 1; 629 (10.5%) as Sadabell 2; and 183 (3.1%) as Sadabell 3. Adjusted hazard ratios for mortality were 2.1 (95%CI 1.9-2.4); 4.0 (95%CI 3.4-4.6); and 21.0 (95%CI 17.2-25.7), respectively. Sabadell 3 patients had 99.9%, 99.5%, 98.5% and 87.4% mortality at 5 years for patients in the age brackets ≥ 80, 60-79, 40-59 and 16-39 years, respectively. Sabadell 2 patients had 71.0%, 52.7%, 44.8% and 23.7% 5-year mortality for these same age categories. The Sabadell score was independently associated with 5-year survival after critical care discharge. These findings can be used to guide provision of increased support for patients after critical care discharge and/or informed discussions with patients and relatives about dying to ascertain their future wishes.
重症监护幸存者与普通人群相比,持续存在发病率和死亡率增加的风险。然而,目前尚无标准化工具来识别高危患者。我们的目的是通过对入住普通重症监护病房的成年人进行前瞻性观察队列研究,确定在重症监护病房出院时由主治医生应用的萨瓦德尔评分是否与 5 年死亡率独立相关。萨瓦德尔评分是一种衡量医生对生存感知的工具,适用于 2011 年 9 月至 2017 年 12 月期间的所有患者。主要结局是使用多变量灵活参数生存分析评估的 5 年死亡率,该分析根据基线特征和临床相关协变量进行了调整。我们研究了 5954 名至少有 18 个月随访的患者。平均(SD)年龄为 59.5(17.0)岁,3397 名(57.1%)患者为男性。我们将 2287 名(38.4%)患者归类为萨瓦德尔 0 分;2854 名(47.9%)为萨瓦德尔 1 分;629 名(10.5%)为萨瓦德尔 2 分;183 名(3.1%)为萨瓦德尔 3 分。调整后的死亡风险比为 2.1(95%CI 1.9-2.4);4.0(95%CI 3.4-4.6);21.0(95%CI 17.2-25.7)。在年龄≥80、60-79、40-59 和 16-39 岁的患者中,萨瓦德尔 3 分患者在 5 年时的死亡率分别为 99.9%、99.5%、98.5%和 87.4%。萨瓦德尔 2 分患者在上述相同年龄组中的 5 年死亡率分别为 71.0%、52.7%、44.8%和 23.7%。萨瓦德尔评分与重症监护后 5 年生存率独立相关。这些发现可用于指导重症监护后为患者提供更多支持,和/或与患者及其家属进行有关临终的知情讨论,以确定他们未来的意愿。