Genesiscare, Inland Drive, Gold Coast, Queensland, Australia.
Brain-Behaviour Research Group, University of New England, Armidale, New South Wales, Australia.
J Med Imaging Radiat Oncol. 2020 Jun;64(3):398-407. doi: 10.1111/1754-9485.13035. Epub 2020 May 4.
The tumour volume of a cancer within the prostate gland is commonly measured with multiparametric MRI. The measurement has a role in many clinical scenarios including focal therapy, but the accuracy of it has never been systematically reviewed. We included articles if they compared tumour volume measurements obtained by mpMRI with a reference volume measurement obtained after radical prostatectomy. Correlation and concordance statistics were summarised. A simple accuracy score was derived by dividing the given mean or median mpMRI volume by the histopathological reference volume. Factors affecting the accuracy were noted. Scores for potential bias and quality were calculated for each article. A total of 18 articles describing 1438 patients were identified. Nine articles gave Pearson's correlation scores, with a median value of 0.75 but the range was wide (0.42-0.97). A total of 11 articles reported mean values for volume while 9 reported median values. For all 18 articles, the mean or median values for MRI volumes were lower than the corresponding reference values suggesting consistent underestimation. For articles reporting mean and median values for volume, the median accuracy scores were 0.83 and 0.80, respectively. The accuracy was higher for tumours of greater volume, higher grade and when an endorectal coil was used. Accuracy did not seem to improve over time, with a 3 Tesla magnet or by applying a shrinkage factor to the reference measurement. Most studies showed evidence of at least moderate bias, and their quality was highly variable, but neither of these appeared to affect accuracy.
前列腺癌肿瘤体积通常通过多参数 MRI 进行测量。这种测量在许多临床情况下都有作用，包括聚焦治疗，但它的准确性从未得到系统的回顾。我们纳入了比较多参数 MRI 测量的肿瘤体积与根治性前列腺切除术后获得的参考体积测量的文章。总结了相关性和一致性统计数据。通过将给定的多参数 MRI 体积的平均值或中位数除以组织病理学参考体积，得出了一个简单的准确性评分。注意到了影响准确性的因素。为每篇文章计算了潜在偏差和质量的评分。共确定了 18 篇描述 1438 例患者的文章。9 篇文章给出了 Pearson 相关系数评分，中位数为 0.75，但范围很广（0.42-0.97）。共有 11 篇文章报告了体积的平均值，9 篇文章报告了中位数。对于所有 18 篇文章，MRI 体积的平均值或中位数均低于相应的参考值，表明存在一致的低估。对于报告体积平均值和中位数的文章，中位数准确性评分为 0.83 和 0.80。肿瘤体积较大、分级较高和使用直肠内线圈时，准确性较高。准确性似乎并没有随着时间的推移而提高，无论是使用 3T 磁铁还是对参考测量值应用收缩因子。大多数研究都显示出至少中度偏倚的证据，其质量高度可变，但这两者似乎都没有影响准确性。
