Key Laboratory of Meat Processing and Quality Control, MOE; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; Key Laboratory of Meat Products Processing, MOA, Nanjing Agricultural University, Nanjing 210095, P. R. China.
Joint International Research Laboratory of Animal Health and Food Safety, MOE, Nanjing Agricultural University, Nanjing 210095, P. R. China.
J Agric Food Chem. 2020 May 27;68(21):5880-5890. doi: 10.1021/acs.jafc.0c00832. Epub 2020 May 13.
More than 90% of serotonin is produced in the intestine. Previous studies have shown that different protein diets significantly affect serum serotonin levels. Here, the colonic microbiota and intestinal serotonin were measured to elaborate how protein diets affect serotonin production in a mouse model. The emulsion-type sausage protein and cooked pork protein diets increased the mRNA levels of tryptophan hydroxylase 1 (Tph1) and monoamine oxidase A (Maoa) and serotonin level as well but reduced the number of enterochromaffin cells. However, the soy protein diet increased the number of enterochromaffin cells and Tph1 mRNA level but decreased the Maoa mRNA level and the serotonin content. Specific gut microbes that responded to dietary changes and affected the content of short-chain fatty acids were significantly related to serotonin-associated biomarkers. These results suggest that dietary proteins may regulate serotonin biosynthesis and catabolism by altering specific gut microbes.
超过 90%的血清素是在肠道中产生的。先前的研究表明，不同的蛋白质饮食会显著影响血清素水平。在这里，我们测量了结肠微生物群和肠道中的血清素，以详细说明蛋白质饮食如何在小鼠模型中影响血清素的产生。乳剂型香肠蛋白和熟猪肉蛋白饮食增加了色氨酸羟化酶 1（Tph1）和单胺氧化酶 A（Maoa）的 mRNA 水平以及血清素水平，但减少了肠嗜铬细胞的数量。然而，大豆蛋白饮食增加了肠嗜铬细胞和 Tph1 mRNA 水平，但降低了 Maoa mRNA 水平和血清素含量。对饮食变化有反应并影响短链脂肪酸含量的特定肠道微生物与与血清素相关的生物标志物显著相关。这些结果表明，膳食蛋白质可能通过改变特定的肠道微生物来调节血清素的生物合成和分解代谢。
