Friedman T C, Fulop G
Department of Community Medicine, Mount Sinai School of Medicine, New York.
J Subst Abuse Treat. 1988;5(3):139-43. doi: 10.1016/0740-5472(88)90002-5.
Disulfiram (Antabuse) is one method for treating alcoholism, despite controversy over its clinical effectiveness. This study examines the hypothesis that hospital-based alcoholism treatment centers would use disulfiram more frequently than free-standing centers in the New York City metropolitan area. A large variation in percentage of patients receiving disulfiram was observed (0%-97%) in both settings. The use of disulfiram at hospital-based centers (27%) was not statistically different from that at free-standing centers (34%). Demography, alternate types of alcoholism treatment offered, and number of physicians on staff did not significantly affect disulfiram use. Personal views of disulfiram by the program director or treating physician were more important determinants of disulfiram use than type of treatment facility. Further study of factors influencing the use of disulfiram by type of alcoholism center may facilitate appropriate referral of patients who may benefit from disulfiram treatment.
双硫仑(戒酒硫)是治疗酒精中毒的一种方法,尽管其临床疗效存在争议。本研究检验了这样一个假设:在纽约市大都市区,医院设立的酒精中毒治疗中心比独立的治疗中心更频繁地使用双硫仑。在这两种环境中,接受双硫仑治疗的患者百分比存在很大差异(0%-97%)。医院设立的治疗中心使用双硫仑的比例(27%)与独立治疗中心(34%)在统计学上没有差异。人口统计学、提供的其他类型酒精中毒治疗以及工作人员中的医生数量并未显著影响双硫仑的使用。项目主任或治疗医生对双硫仑的个人看法比治疗机构的类型更能决定双硫仑的使用。进一步研究酒精中毒治疗中心类型对双硫仑使用的影响因素,可能有助于将可能从双硫仑治疗中受益的患者进行适当转诊。