EDGE Lab, School of Psychology, University of Sussex, Brighton, UK.
School of Psychology, University of Sussex, Brighton, UK.
Aging Ment Health. 2021 Sep;25(9):1642-1648. doi: 10.1080/13607863.2020.1758916. Epub 2020 May 2.
There is an association between affective symptoms and cognition. However, the direction of this association remains unclear. This study aimed to test bidirectional relationships between affective symptoms and cognition from middle to late adulthood.
Data were available from the MRC National Survey of Health and Development (NSHD), a prospective birth cohort of 5362 people born in 1946. Affective symptoms and cognition were measured at ages 53, 60-64, and 69. Latent scores of affective symptoms were derived and cross-lagged models were fitted for affective symptoms with verbal memory and processing speed.
Results revealed an inverse cross-sectional association between affective symptoms and verbal memory (β=-0.18, SE=0.04, <.001) and processing speed (β=-0.13, SE=0.06, =.05) at age 53, but not at ages 60-64 or 69. Affective symptoms at age 53 predicted lower verbal memory at age 60-64 (β=-0.58, SE=0.27, =.03), and affective symptoms at age 60-64 predicted lower verbal memory (β=-0.64, SE=0.29, =.03) and processing speed (β=-1.27, SE=0.41, =.002) at age 69. Verbal memory and processing speed did not predict subsequent affective symptoms.
Affective symptoms predict poorer verbal memory and processing speed over a period of 16 years, but not vice versa.
情感症状与认知之间存在关联。然而，这种关联的方向尚不清楚。本研究旨在测试从中年到晚年情感症状与认知之间的双向关系。
数据来自 MRC 国家健康与发展调查（NSHD），这是一项对 1946 年出生的 5362 人的前瞻性出生队列研究。在 53 岁、60-64 岁和 69 岁时测量了情感症状和认知。得出了情感症状的潜在分数，并为情感症状与言语记忆和处理速度拟合了交叉滞后模型。
结果显示，53 岁时情感症状与言语记忆（β=-0.18，SE=0.04，<.001）和处理速度（β=-0.13，SE=0.06，=.05）之间存在反向横断面关联，但在 60-64 岁或 69 岁时则没有。53 岁时的情感症状预测了 60-64 岁时言语记忆较低（β=-0.58，SE=0.27，=.03），而 60-64 岁时的情感症状预测了 69 岁时言语记忆（β=-0.64，SE=0.29，=.03）和处理速度（β=-1.27，SE=0.41，=.002）较低。言语记忆和处理速度均不能预测随后的情感症状。
情感症状在 16 年内预测言语记忆和处理速度较差，但反之则不然。
