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电针通过调节慢性不可预测轻度应激大鼠海马中的5-HT1A受体来改善突触可塑性。

Electroacupuncture improves synaptic plasticity by regulating the 5-HT1A receptor in hippocampus of rats with chronic unpredictable mild stress.

作者信息

Chen Lixing, Yao Zengyu, Qu Shanshan, Zhang Jialing, Zhang Jiping, Zhang Zhinan, Huang Yong, Zhong Zheng

机构信息

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.

School of Chinese Medicine, The University of Hong Kong, Hong Kong.

出版信息

J Int Med Res. 2020 May;48(5):300060520918419. doi: 10.1177/0300060520918419.

DOI:10.1177/0300060520918419
PMID:32363965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7221223/
Abstract

OBJECTIVES

To investigate the antidepressant effects of electroacupuncture (EA) on chronic unpredictable mild stress (CUMS) in rats, as well as the effects of EA on hippocampal neurons, synaptic morphology, and 5-hydroxytryptamine (HT) receptor expression.

METHODS

Forty adult male Wistar rats were randomly divided into normal control, CUMS, EA, and paroxetine groups. CUMS modeling was performed for 21 days, followed by 14 days of intervention: rats in the EA group underwent stimulation of GV20 and GV29 acupuncture points for 30 minutes daily; rats in the paroxetine group were administered paroxetine daily. Behavioral tests, transmission electron microscopy, western blotting, and real-time quantitative polymerase chain reaction were used to evaluate the effects of the intervention.

RESULTS

EA treatment reversed the behavioral changes observed in rats due to CUMS modeling; it also improved the pathological changes in organelles and synaptic structures of hippocampal neurons, and upregulated the protein and mRNA expression levels of 5-HT1A receptor. There were no significant differences in 5-HT1B receptor protein and mRNA expression levels among the groups.

CONCLUSIONS

EA treatment can alleviate depression-like symptoms in CUMS rats. The underlying mechanism may include promoting the expression of 5-HT1A receptor mRNA and protein, thereby improving synaptic plasticity in the hippocampus.

摘要

目的

探讨电针（EA）对大鼠慢性不可预测性轻度应激（CUMS）的抗抑郁作用，以及EA对海马神经元、突触形态和5-羟色胺（HT）受体表达的影响。

方法

将40只成年雄性Wistar大鼠随机分为正常对照组、CUMS组、EA组和帕罗西汀组。进行21天的CUMS造模，随后进行14天的干预：EA组大鼠每天针刺GV20和GV29穴位30分钟；帕罗西汀组大鼠每天给予帕罗西汀。采用行为学测试、透射电子显微镜、蛋白质印迹法和实时定量聚合酶链反应来评估干预效果。

结果

EA治疗逆转了CUMS造模大鼠所观察到的行为变化；还改善了海马神经元细胞器和突触结构的病理变化，并上调了5-HT1A受体的蛋白质和mRNA表达水平。各组之间5-HT1B受体蛋白质和mRNA表达水平无显著差异。

结论

EA治疗可减轻CUMS大鼠的抑郁样症状。其潜在机制可能包括促进5-HT1A受体mRNA和蛋白质的表达，从而改善海马的突触可塑性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/c0eb0111d2bb/10.1177_0300060520918419-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/556eac9b4abe/10.1177_0300060520918419-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/e7e328e200fc/10.1177_0300060520918419-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/117aee75f29c/10.1177_0300060520918419-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/c2f2bc6de40f/10.1177_0300060520918419-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/c0eb0111d2bb/10.1177_0300060520918419-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/556eac9b4abe/10.1177_0300060520918419-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/e7e328e200fc/10.1177_0300060520918419-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/117aee75f29c/10.1177_0300060520918419-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/c2f2bc6de40f/10.1177_0300060520918419-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be1/7221223/c0eb0111d2bb/10.1177_0300060520918419-fig5.jpg

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