Ribero S, Zugna D, Spector T, Bataille V
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Dermatology Clinic, University of Turin, Turin, Italy.
Br J Dermatol. 2021 Feb;184(2):289-295. doi: 10.1111/bjd.19171. Epub 2021 Feb 1.
Naevi number changes with age. Thus, a better understanding of naevus biology will shed more light on the genetic and environmental factors involved in melanoma development.
To use a two-wave study to better understand the evolution of naevi in healthy adults.
This study is a prospective two-wave study based on adult twins from the TwinsUK registry (n = 414) who underwent total body naevus counts with an interval of at least 15 years. A negative binomial hierarchical model with two levels, the individual and the twin pair, was used to estimate expected changes in naevus count between the first and second visit, at any specific body site and on the whole body. The model was adjusted for age, calendar year at the first visit, height and skin type.
The mean age of participants was 46 years at the first visit and 63 years at the second visit (the mean elapsed time between visits was 17 years). An increase in naevus count was observed in 235 (57%) participants and a decrease was observed in 166 (40%). The mean difference in total naevus count between the two visits was nine. The expected total body naevus count increased, on a logarithmic scale, by 0·28 [95% confidence interval (CI) 0·16-0·40] with a change in the incidence rate of total body naevus count of 32% (95% CI 17-49%). However, the observed increase in naevus count over time was observed only on the upper parts of the body, whereas there was no evidence of an increase on the lower parts.
Naevus counts increased slightly over time at older ages, but this was dependent on body site. The overall decrease in naevus counts previously reported in cross-sectional studies has not been confirmed by this longitudinal study.
痣的数量随年龄变化。因此，更好地了解痣的生物学特性将有助于更深入地了解黑色素瘤发生过程中的遗传和环境因素。
通过两波研究更好地了解健康成年人痣的演变情况。
本研究是一项前瞻性两波研究，基于来自双胞胎英国注册库（n = 414）的成年双胞胎，他们至少间隔15年进行了全身痣计数。使用具有个体和双胞胎对两个层次的负二项分层模型来估计首次和第二次就诊之间、任何特定身体部位以及全身痣计数的预期变化。该模型针对年龄、首次就诊的日历年、身高和皮肤类型进行了调整。
参与者首次就诊时的平均年龄为46岁，第二次就诊时为63岁（两次就诊之间的平均间隔时间为17年）。235名（57%）参与者的痣计数增加，166名（40%）参与者的痣计数减少。两次就诊之间总痣计数的平均差异为9。全身痣计数预期增加，以对数尺度计，为0·28 [95%置信区间（CI）0·16 - 0·40]，全身痣计数发病率变化为32%（95% CI 17 - 49%）。然而，随着时间推移观察到的痣计数增加仅出现在身体上部，而没有证据表明身体下部有增加。
随着年龄增长，痣计数随时间略有增加，但这取决于身体部位。此前横断面研究中报道的痣计数总体下降未得到本纵向研究的证实。
