• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Desmosome-Dyad Crosstalk: An Arrhythmogenic Axis in Arrhythmogenic Right Ventricular Cardiomyopathy.

作者信息

Delmar Mario, Alvarado Francisco J, Valdivia Héctor H

机构信息

The Leon H Charney Division of Cardiology. New York University School of Medicine (M.D.).

Department of Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health. Madison (F.J.A., H.H.V.).

出版信息

Circulation. 2020 May 5;141(18):1494-1497. doi: 10.1161/CIRCULATIONAHA.120.046020. Epub 2020 May 4.

DOI:10.1161/CIRCULATIONAHA.120.046020
PMID:32364772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7384448/
Abstract
摘要

相似文献

1
Desmosome-Dyad Crosstalk: An Arrhythmogenic Axis in Arrhythmogenic Right Ventricular Cardiomyopathy.桥粒-二联体串扰：致心律失常性右室心肌病中的致心律失常轴
Circulation. 2020 May 5;141(18):1494-1497. doi: 10.1161/CIRCULATIONAHA.120.046020. Epub 2020 May 4.
2
Disruption of Ca Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice.钙稳态破坏和缝隙连接蛋白 43 半通道功能障碍先于桥粒斑蛋白-2 缺陷小鼠出现显性致心律失常性心肌病。
Circulation. 2019 Sep 17;140(12):1015-1030. doi: 10.1161/CIRCULATIONAHA.119.039710. Epub 2019 Jul 18.
3
Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts.运动引起桥粒斑蛋白 2 缺陷心脏细胞内钙动力学的致心律失常重构。
Circulation. 2022 May 10;145(19):1480-1496. doi: 10.1161/CIRCULATIONAHA.121.057757. Epub 2022 May 1.
4
Desmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndrome.桥粒与钠通道复合物：对致心律失常性心肌病和Brugada综合征的影响。
Trends Cardiovasc Med. 2014 Jul;24(5):184-90. doi: 10.1016/j.tcm.2014.02.001. Epub 2014 Feb 22.
5
Arrhythmogenic right ventricular cardiomyopathy plakophilin-2 mutations disrupt desmosome assembly and stability.致心律失常性右室心肌病盘状球蛋白2突变破坏桥粒组装和稳定性。
Cell Commun Adhes. 2009;16(1-3):15-27. doi: 10.1080/15419060903009329.
6
PKP2 mutations in sudden death from arrhythmogenic right ventricular cardiomyopathy (ARVC) and sudden unexpected death with negative autopsy (SUDNA).PKP2 突变与心律失常性右室心肌病（ARVC）和阴性尸检的猝死（SUDNA）。
Circ J. 2012;76(1):189-94. doi: 10.1253/circj.cj-11-0747. Epub 2011 Oct 22.
7
Clinical Findings and Diagnostic Yield of Arrhythmogenic Cardiomyopathy Through Genomic Screening of Pathogenic or Likely Pathogenic Desmosome Gene Variants.通过对致病性或可能致病性桥粒基因变异的基因组筛查发现心律失常性心肌病的临床特征和诊断效果。
Circ Genom Precis Med. 2021 Apr;14(2):e003302. doi: 10.1161/CIRCGEN.120.003302. Epub 2021 Mar 8.
8
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.桥粒蛋白盘状球蛋白2的突变在致心律失常性右室心肌病中很常见。
Nat Genet. 2004 Nov;36(11):1162-4. doi: 10.1038/ng1461. Epub 2004 Oct 17.
9
Arrhythmogenic cardiomyopathy and Brugada syndrome: diseases of the connexome.致心律失常性右室心肌病和 Brugada 综合征：连接子心肌病。
FEBS Lett. 2014 Apr 17;588(8):1322-30. doi: 10.1016/j.febslet.2014.02.008. Epub 2014 Feb 15.
10
Left-dominant arrhythmogenic cardiomyopathy in a large family: associated desmosomal or nondesmosomal genotype?左侧优势型致心律失常性右室心肌病的一个大家族：相关桥粒或非桥粒基因型？
Heart Rhythm. 2013 Apr;10(4):548-59. doi: 10.1016/j.hrthm.2012.12.020. Epub 2012 Dec 25.

引用本文的文献

1
Subepicardial Cardiomyopathy: A Disease Underlying J-Wave Syndromes and Idiopathic Ventricular Fibrillation.心外膜下心肌病：一种引发 J 波综合征和特发性心室颤动的疾病。
Circulation. 2023 May 23;147(21):1622-1633. doi: 10.1161/CIRCULATIONAHA.122.061924. Epub 2023 May 22.
2
Ca dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide.心脏基质细胞中的钙失调可维持心律失常性心肌病中的纤维脂肪重塑，而氟卡尼可调节这种重塑。
J Transl Med. 2022 Nov 12;20(1):522. doi: 10.1186/s12967-022-03742-8.
3
Clinical Findings and Diagnostic Yield of Arrhythmogenic Cardiomyopathy Through Genomic Screening of Pathogenic or Likely Pathogenic Desmosome Gene Variants.通过对致病性或可能致病性桥粒基因变异的基因组筛查发现心律失常性心肌病的临床特征和诊断效果。
Circ Genom Precis Med. 2021 Apr;14(2):e003302. doi: 10.1161/CIRCGEN.120.003302. Epub 2021 Mar 8.

本文引用的文献

1
Integrin β1D Deficiency-Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy.整合素β1D 缺乏介导的 RyR2 功能障碍导致儿茶酚胺敏感性室性心动过速在致心律失常性右心室心肌病中的作用。
Circulation. 2020 May 5;141(18):1477-1493. doi: 10.1161/CIRCULATIONAHA.119.043504. Epub 2020 Mar 3.
2
Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy.心律失常性心肌病免疫反应的治疗调节。
Circulation. 2019 Oct 29;140(18):1491-1505. doi: 10.1161/CIRCULATIONAHA.119.040676. Epub 2019 Sep 19.
3
Disruption of Ca Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice.钙稳态破坏和缝隙连接蛋白 43 半通道功能障碍先于桥粒斑蛋白-2 缺陷小鼠出现显性致心律失常性心肌病。
Circulation. 2019 Sep 17;140(12):1015-1030. doi: 10.1161/CIRCULATIONAHA.119.039710. Epub 2019 Jul 18.
4
Molecular mechanisms of arrhythmogenic cardiomyopathy.致心律失常性右室心肌病的分子机制。
Nat Rev Cardiol. 2019 Sep;16(9):519-537. doi: 10.1038/s41569-019-0200-7.
5
Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart.心肌细胞 PKA 消融增强基础收缩力，同时消除心脏 β-肾上腺素能反应，而对心脏无不良影响。
Circ Res. 2019 Jun 7;124(12):1760-1777. doi: 10.1161/CIRCRESAHA.118.313417. Epub 2019 Apr 15.
6
Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic.非天然 verticilide 对映异构体抑制 2 型 Ryanodine 受体介导的钙泄漏，具有抗心律失常作用。
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4810-4815. doi: 10.1073/pnas.1816685116. Epub 2019 Feb 21.
7
Cardiac sympathectomy for refractory ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy.心律失常性右室心肌病致难治性室性心动过速的心脏去交感神经术。
Heart Rhythm. 2019 Jul;16(7):1003-1010. doi: 10.1016/j.hrthm.2019.01.019. Epub 2019 Jan 21.
8
Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response.ryanodine 受体 2 丝氨酸 2030 位点的磷酸化是完全β-肾上腺素能反应所必需的。
J Gen Physiol. 2019 Feb 4;151(2):131-145. doi: 10.1085/jgp.201812155. Epub 2018 Dec 12.
9
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.桥粒芯蛋白-2是控制钙循环和心律的基因转录所必需的。
Nat Commun. 2017 Jul 24;8(1):106. doi: 10.1038/s41467-017-00127-0.
10
Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial.氟卡尼治疗儿茶酚胺敏感性多形性室性心动过速的疗效：一项随机临床试验。
JAMA Cardiol. 2017 Jul 1;2(7):759-766. doi: 10.1001/jamacardio.2017.1320.