Jennings T, Rusin M M, Tessler H H, Cunha-Vaz J G
Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, College of Medicine, Chicago 60612.
Jpn J Ophthalmol. 1988;32(4):385-91.
Cystoid macular edema (CME) is a major cause of visual impairment and is thought to be due to abnormal perifoveal capillary permeability. Posterior sub-Tenon's corticosteroid injections are used to improve the visual acuity in CME, although their mechanism of action is uncertain. In this study, visual acuity, blood retinal barrier (BRB) permeability, and fluorescein angiograms were recorded immediately before and one and four weeks after the administration of steroid injections. Ten patients (12 treated eyes) with CME secondary to uveitis were studied. Visual improvement, defined as an increase in at least two lines of Snellen visual acuity, was seen in half of the treated eyes. In some patients, these improvements were not directly related to changes in the BRB permeability or the amount of macular fluid. Posterior sub-Tenon's corticosteroid injections do not consistently affect blood retinal barrier permeability.
黄斑囊样水肿（CME）是视力损害的主要原因，被认为是由于黄斑中心凹周围毛细血管通透性异常所致。尽管其作用机制尚不确定，但后Tenon囊下注射皮质类固醇用于改善CME患者的视力。在本研究中，在注射类固醇之前以及注射后1周和4周时，记录视力、血视网膜屏障（BRB）通透性和荧光素血管造影结果。对10例（12只治疗眼）葡萄膜炎继发CME的患者进行了研究。在半数治疗眼中观察到视力改善，定义为Snellen视力至少提高两行。在一些患者中，这些改善与BRB通透性或黄斑区积液量的变化没有直接关系。后Tenon囊下注射皮质类固醇并不能始终影响血视网膜屏障的通透性。
