Mathematics and Statistics, Concordia University, Montreal, Quebec, Canada
PERFORM Centre, Montreal, Canada.
J Epidemiol Community Health. 2020 Aug;74(8):662-667. doi: 10.1136/jech-2019-213419. Epub 2020 May 4.
Whether weight cycling (repeated weight loss and regain) is associated with cardiometabolic health is unclear. Study objective was to examine whether weight cycling since young adulthood (ie, 25 years of age) was associated with cardiometabolic markers.
Data from a nationally representative cross-sectional US sample (National Health and Nutrition Examination Survey, 1999-2014) were used. Weight history was based on self-reported weight at age 25, 10 years prior and 1 year prior to the survey (n=4190, 51% male). Using current self-reported weight as the anchor, participants were classified as (1) (2) , (3) and (4) . Cardiometabolic markers included fasting lipids, insulin sensitivity and blood pressure. Multiple linear regressions were used to analyse weight history (reference: ) and adjusted for covariates. Analyses incorporated the sampling design and survey weights and were stratified by sex or weight status.
Compared with females with , female had worse lipids and homeostasis model assessment for insulin resistance (HOMA-IR) (all ps<0.05). Compared with males with stable weight, male weight cyclers had worse high-density lipoprotein cholesterol (HDL) and HOMA-IR (ps<0.05). Weight cyclers with normal weight had worse HDL and low-density lipoprotein cholesterol (ps<0.05), and weight cyclers with overweight or obesity had worse HOMA-IR (p=0.05). Blood pressure was not associated.
Weight cycling is adversely associated with cardiometabolic markers but associations differ by sex and weight status. While weight cycling is consistently associated with worse cardiometabolic markers among females, results are mixed among males. Weight cycling is associated with worse lipid measures for normal weight persons, and marginally worse insulin sensitivity for those with overweight/obesity.
体重波动（反复减重和增重）是否与心血管代谢健康有关尚不清楚。本研究旨在探讨成年早期（即 25 岁）开始的体重波动是否与心血管代谢标志物相关。
本研究使用了来自美国全国代表性横断面调查（国家健康和营养调查，1999-2014 年）的数据。体重史基于调查前 1 年、10 年前和 25 岁时的自我报告体重（n=4190，51%为男性）。根据当前的自我报告体重，参与者被分为以下四组：（1） ；（2） ；（3） ；和（4） 。心血管代谢标志物包括空腹血脂、胰岛素敏感性和血压。使用多元线性回归分析体重史（参考： ），并调整了协变量。分析纳入了抽样设计和调查权重，并按性别或体重状况进行分层。
与女性相比，女性 的血脂和稳态模型评估的胰岛素抵抗（HOMA-IR）更差（均 P<0.05）。与稳定体重的男性相比，男性体重波动者的高密度脂蛋白胆固醇（HDL）和 HOMA-IR 更差（均 P<0.05）。体重正常波动者的 HDL 和低密度脂蛋白胆固醇更差（均 P<0.05），超重或肥胖的体重波动者的 HOMA-IR 更差（P=0.05）。血压与体重波动无关。
体重波动与心血管代谢标志物呈负相关，但关联因性别和体重状况而异。虽然体重波动与女性的心血管代谢标志物更差始终相关，但男性的结果则各不相同。体重波动与正常体重者的脂质指标更差相关，与超重/肥胖者的胰岛素敏感性略差相关。
