Zeigler Zachary S, Birchfield Natasha, Moreno Karen, James Darith, Swan Pamela
College of Science, Engineering, and Technology, Grand Canyon University, Phoenix, Arizona.
School of Nutrition and Health Promotion, Arizona State University, Phoenix, Arizona.
Biores Open Access. 2018 Jun 1;7(1):90-100. doi: 10.1089/biores.2017.0044. eCollection 2018.
Weight Cycling (WC) is a prevalent behavior associated with adverse cardiovascular (CV) health. However, a 2010 review on the effects of WC and blood pressure (BP) determined that there was not enough evidence to draw definitive conclusions. Central BP is the principal predictor of CV risk compared to peripheral BP. The influence that WC may have specifically on central BP is unknown. Cross-sectional observation of self-reported history of WC on measures of CV health was undertaken. Seventy-five women completed a Weight and Lifestyle Inventory questionnaire, which is considered a reliable index of WC ( = 0.87, < 0.001). Measures of visceral fat, BP, arterial stiffness, and VOpeak were taken. Regression equations were used to assess primary predictors of these outcomes. Seventy-five middle aged (39 ± 11 years), obese (32 ± 7 kg/m), and relatively unfit (24 ± 8 ml·kg min) women completed the study. Visceral fat was the strongest predictor of brachial systolic blood pressure (SBP; = 0.283), brachial diastolic blood pressure (DBP; = 0.176), central SBP ( = 0.375), and augmentation index (AIx; = 0.535, all < 0.001). VOpeak was the strongest predictor of central DBP ( = 0.062, = 0.036) and augmentation pressure (AP; = 0.491, < 0.001). Weight cycling index was associated with visceral fat ( = 0.521, < 0.001). Visceral fat was a mediator between WC and central SBP (confidence interval [CI] = 0.0053-0.0602), AP (CI = 0.0507-0.4915), AIx (CI = 0.0025-0.0699), and carotid-femoral pulse wave velocity (CI = 0.0115-0.1227; all < 0.05). WC may increase visceral fat accumulation, which was associated with increased central SBP and measures of arterial stiffness.
体重循环（WC）是一种与不良心血管（CV）健康相关的普遍行为。然而，2010年一项关于WC与血压（BP）影响的综述确定，没有足够的证据得出明确结论。与外周血压相比，中心血压是CV风险的主要预测指标。WC对中心血压可能产生的具体影响尚不清楚。对自我报告的WC病史与CV健康指标进行了横断面观察。75名女性完成了一份体重与生活方式调查问卷，该问卷被认为是WC的可靠指标（=0.87，<0.001）。测量了内脏脂肪、血压、动脉僵硬度和峰值摄氧量（VOpeak）。使用回归方程评估这些结果的主要预测因素。75名中年（39±11岁）、肥胖（32±7kg/m）且身体相对不健康（24±8ml·kg-1·min-1）的女性完成了该研究。内脏脂肪是肱动脉收缩压（SBP；=0.283）、肱动脉舒张压（DBP；=0.176）、中心SBP（=0.375）和增强指数（AIx；=0.535，均<0.001）的最强预测因素。VOpeak是中心DBP（=0.062，=0.036）和增强压（AP；=0.491，<0.001）的最强预测因素。体重循环指数与内脏脂肪相关（=0.521，<0.001）。内脏脂肪是WC与中心SBP（置信区间[CI]=0.0053 - 0.0602）、AP（CI=0.0507 - 0.4915）、AIx（CI=0.0025 - 0.0699）和颈股脉搏波速度（CI=0.0115 - 0.1227；均<0.05）之间的中介因素。WC可能会增加内脏脂肪堆积，这与中心SBP升高和动脉僵硬度指标增加有关。
