Grabenbauer G G, Herbst M A, Völcker H E
Strahlentherapeutische Klinik und Poliklinik der Universität Erlangen-Nürnberg.
Klin Monbl Augenheilkd. 1988 Sep;193(3):283-6. doi: 10.1055/s-2008-1050259.
The effect of fractionated 300 kV roentgen radiation on different sections of the eye (cornea, ciliary body, retina, and choroid) was investigated in 36 rabbits. Four groups of nine animals each were exposed to 21, 30, 36, and 45 Gy in constant fractions of 5 x 3 Gy per week. After three weeks, three months, and six months three animals from each group were killed. Both eyeballs, the eyelids, and the lacrimal glands were removed, fixed, and embedded in paraffin. The 15 sections made of each specimen were stained according to PAS and HE. The application of total doses of 21, 30, and 36 Gy did not lead to any histopathologically discernible alterations. Only in one animal was an ulcerating keratitis seen to develop within three months in response to a dose of 45 Gy. In the same group, a perilimbic conjunctival inflammation developed in three animals after six months and in two after three months. All animals which had received doses of 45 Gy and were examined after six months were found to have a vacuolic swelling of the ciliary epithelium. In one animal which had received a dose of 45 Gy a myointimal proliferation of a ciliary artery was seen three months after termination of the treatment.
在36只兔子身上研究了分次300 kV伦琴射线辐射对眼睛不同部位（角膜、睫状体、视网膜和脉络膜）的影响。将36只兔子分为四组，每组9只，分别接受21、30、36和45 Gy的辐射，每周固定剂量为5×3 Gy。三周、三个月和六个月后，每组处死3只动物。取出双眼球、眼睑和泪腺，固定后石蜡包埋。每个标本制作15张切片，分别进行PAS和HE染色。21、30和36 Gy的总剂量照射未导致任何组织病理学上可辨别的改变。仅在一只接受45 Gy照射的动物中，三个月内出现了溃疡性角膜炎。在同一组中，六个月后有3只动物出现角膜缘周围结膜炎症，三个月后有2只出现。所有接受45 Gy照射并在六个月后检查的动物均发现睫状体上皮有空泡样肿胀。在一只接受45 Gy照射的动物中，治疗结束三个月后可见睫状动脉肌内膜增生。
