• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

角膜对远紫外线的反应:一项超微结构研究。

Response of the cornea to far ultraviolet light: an ultrastructural study.

作者信息

Koliopoulos J X, Margaritis L H

出版信息

Ann Ophthalmol. 1979 May;11(5):765-9.

PMID:464507
Abstract

Quantitative changes were measured and ultrastructural alterations were detected in rabbit corneas after exposure to a far ultraviolet irradiation (UV). Low dose exposure (105 - 8 x 105 erg/cm2) resulted one day later in a thicker epithelium and loss of the intercellular permeability barrier. In corneas exposed to higher doses (5 x 106 erg/cm2), the epithelium was considerably thinner one day later, whereas 4 days later it was of normal thickness and the endothelial cells became degenerated. The highest UV dose exposure used (a total of 20 x 106 erg/cm2 given in 4 equal daily doses) resulted in (1) swelling of the stroma and disorganization of the collagen fibers; (2) disappearance of the basement membrane; (3) degeneration of the endothelial cells; and (4) considerable reduction of epithelium thickness.

摘要

对暴露于远紫外线(UV)照射后的兔角膜进行了定量变化测量并检测了超微结构改变。低剂量照射(105 - 8×105尔格/平方厘米)一天后导致上皮增厚以及细胞间通透性屏障丧失。在暴露于较高剂量(5×106尔格/平方厘米)的角膜中,一天后上皮明显变薄,而4天后其厚度恢复正常但内皮细胞发生退化。所使用的最高紫外线剂量照射(以4个相等的日剂量总共给予20×106尔格/平方厘米)导致:(1)基质肿胀和胶原纤维紊乱;(2)基底膜消失;(3)内皮细胞退化;以及(4)上皮厚度显著降低。

相似文献

1
Response of the cornea to far ultraviolet light: an ultrastructural study.角膜对远紫外线的反应:一项超微结构研究。
Ann Ophthalmol. 1979 May;11(5):765-9.
2
Quantitative changes and ultrastructural alterations of the cornea in response to ultraviolet light. II. Effects of amphibia; elucidation of desmosomal structure and basement membrane synthesis.
Tissue Cell. 1976;8(4):603-14. doi: 10.1016/0040-8166(76)90034-3.
3
Morphological response to UV-B irradiation after excimer-laser photorefractive keratectomy.准分子激光屈光性角膜切削术后对UV-B照射的形态学反应
Ger J Ophthalmol. 1996 Nov;5(6):352-61.
4
Protective role of corneal epithelium against ultraviolet radiation damage.角膜上皮对紫外线辐射损伤的保护作用。
Acta Ophthalmol Scand. 2004 Dec;82(6):714-7. doi: 10.1111/j.1600-0420.2004.00369.x.
5
Cellular response and reactive hyaluronan production in UV-exposed rabbit corneas.紫外线照射的兔角膜中的细胞反应和活性透明质酸生成
Cornea. 1998 Nov;17(6):640-5. doi: 10.1097/00003226-199811000-00012.
6
Development and repair of cataract induced by ultraviolet radiation.紫外线诱导白内障的发生与修复
Ophthalmic Res. 2000;32 Suppl 1:ii-iii; 1-44.
7
[The function of the posterior corneal epithelium after exposure to ultraviolet laser radiation].[暴露于紫外激光辐射后角膜后上皮的功能]
Oftalmol Zh. 1990(3):173-6.
8
Hydration and transparency of the rabbit cornea irradiated with UVB-doses of 0.25 J/cm(2) and 0.5 J/cm(2) compared with equivalent UVB radiation exposure reaching the human cornea from sunlight.比较兔眼角膜在接受 0.25 J/cm(2) 和 0.5 J/cm(2) 的 UVB 剂量照射以及相当于阳光到达人眼角膜的 UVB 辐射暴露后的水合作用和透明度。
Curr Eye Res. 2011 Jul;36(7):607-13. doi: 10.3109/02713683.2011.574332. Epub 2011 May 20.
9
Effect of two different UVA doses on the rabbit cornea and lens.两种不同紫外线A剂量对兔角膜和晶状体的影响。
Photochem Photobiol. 2009 May-Jun;85(3):794-800. doi: 10.1111/j.1751-1097.2008.00478.x. Epub 2008 Dec 8.
10
Light absorption properties of the rabbit cornea repeatedly irradiated with UVB rays.经紫外线B反复照射的兔角膜的光吸收特性。
Photochem Photobiol. 2007 May-Jun;83(3):652-7. doi: 10.1111/j.1751-1097.2007.00061.x.

引用本文的文献

1
Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium.活性依赖的神经保护蛋白(ADNP)衍生肽(NAP)可对抗紫外线B辐射诱导的角膜上皮细胞活性氧生成。
Antioxidants (Basel). 2022 Jan 7;11(1):128. doi: 10.3390/antiox11010128.
2
The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard.兔眼角膜器官培养物经 UVB 光和氮芥处理后产生的 4-羟壬烯醛,一种亲电脂质过氧化终产物。
Toxicol Appl Pharmacol. 2013 Oct 15;272(2):345-55. doi: 10.1016/j.taap.2013.06.025. Epub 2013 Jul 9.
3
Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression.
海藻糖对 UVB 诱导的角膜上皮抗氧化/促氧化失衡、促炎细胞因子和基质金属蛋白酶诱导以及热休克蛋白 70 表达的发展的有利影响。
Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1185-94. doi: 10.1007/s00417-011-1676-y. Epub 2011 Apr 15.
4
The influence of various toxic effects on the cornea and changes in corneal light transmission.各种毒性作用对角膜的影响及角膜透光性的变化。
Graefes Arch Clin Exp Ophthalmol. 2010 Dec;248(12):1749-56. doi: 10.1007/s00417-010-1438-2. Epub 2010 Jul 2.
5
Ultraviolet induced lysosome activity in corneal epithelium.紫外线诱导角膜上皮中的溶酶体活性。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;214(2):107-18. doi: 10.1007/BF00572789.