Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.
Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, P.R. China.
Muscle Nerve. 2020 Aug;62(2):214-218. doi: 10.1002/mus.26905. Epub 2020 Jun 7.
We assessed clinical predictors of mechanical ventilation in children with Guillain-Barré syndrome (GBS) to help identify patients who require mechanical ventilation.
We retrospectively collected the clinical, laboratory, and electrophysiological data of 103 children with GBS. Patients were categorized into two groups based on the requirement for mechanical ventilation. Variables that were significantly different between the two groups in univariate analysis were analyzed by multivariate logistic regression models.
Time from symptom onset to admission (P = .002), facial or bulbar weakness (P = .001), and axonal type (P = .005) were associated with mechanical ventilation in univariate analysis. In multivariate analysis, facial or bulbar weakness (odds ratio [OR], 7.936; P = .013) and axonal type (OR, 4.582; P = .022) were independent predictors for mechanical ventilation.
Facial or bulbar weakness and axonal type were associated with increased risk for mechanical ventilation in children with GBS.
我们评估了格林-巴利综合征（GBS）患儿机械通气的临床预测因素，以帮助识别需要机械通气的患者。
我们回顾性收集了 103 例 GBS 患儿的临床、实验室和电生理数据。根据机械通气的需要，将患者分为两组。单因素分析中两组间差异有统计学意义的变量采用多因素逻辑回归模型进行分析。
发病至入院时间（P =.002）、面部或球部无力（P =.001）和轴索性（P =.005）与机械通气有关。多因素分析中，面部或球部无力（比值比 [OR]，7.936；P =.013）和轴索性（OR，4.582；P =.022）是机械通气的独立预测因素。
面部或球部无力和轴索性与 GBS 患儿机械通气风险增加有关。
