Fogliata A, Cayez R, Garcia R, Khamphan C, Reggiori G, Scorsetti M, Cozzi L
Humanitas Clinical and Research Center - IRCCS, Radiotherapy Dept, via Manzoni 56, 20089, Milan, Rozzano, Italy.
Oscar Lambret Center, rue Frédéric Combemale, Radiotherapy, 59000, Lille, France.
Med Phys. 2020 Aug;47(8):3669-3674. doi: 10.1002/mp.14217. Epub 2020 May 23.
The use of flattening filter free (FFF) beams generated by standard linear accelerators is increasing in the clinical practice. The radiation intensity peaked toward the beam central axis is properly managed in the optimization process of treatment planning through intensity modulation. Specific FFF parameters for profile analysis, as unflatness and slope for FFF beams, based on the renormalization factor concept has been introduced for quality assurance purposes. Recently, Halcyon, an O-ring based linear accelerator equipped with a 6 MV FFF beam only has been introduced by Varian.
Renormalization factors and related fit parameters according to Fogliata et al. ["Definition of parameters for quality assurance of FFF photon beams in radiation therapy," Med. Phys. 39, 6455-6464 (2012)] have been evaluated for the 6 MV FFF beam generated by Halcyon units. The Halcyon representative beam data provided by Varian were used. Dose fall-off at the field edges was matched with an unflattened beam generated by a 6 MV from a TrueBeam linac. Consistency of the results was evaluated against measurements on a clinical Halcyon unit, as well as a TrueBeam 6 MV FFF for comparison.
The five parameters in the analytical equation for estimating the renormalization factor were determined with an R of 0.997. The comparison of the unflatness parameters between the Halcyon representative and hospital beam data was consistent within a range of 0.6%. Consistently with the computed parameters, the Halcyon profiles resulted in a less pronounced peak than TrueBeam.
Renormalization factors and related fit parameters from the 6 MV FFF beam generated by the Varian Halcyon unit are provided.
标准直线加速器产生的无 flattening 滤波器(FFF)束流在临床实践中的应用正在增加。在治疗计划的优化过程中,通过强度调制对朝向束流中心轴达到峰值的辐射强度进行了适当管理。基于归一化因子概念,已引入用于轮廓分析的特定 FFF 参数,如 FFF 束流的不平整度和斜率,用于质量保证目的。最近,Varian 推出了 Halcyon,这是一种仅配备 6MV FFF 束流的基于 O 型环的直线加速器。
根据 Fogliata 等人的研究[《放射治疗中 FFF 光子束质量保证参数的定义》,《医学物理》39,6455 - 6464(2012)],对 Halcyon 装置产生的 6MV FFF 束流的归一化因子和相关拟合参数进行了评估。使用了 Varian 提供的 Halcyon 代表性束流数据。将射野边缘处的剂量下降与 TrueBeam 直线加速器产生的 6MV 未 flatten 束流相匹配。根据在临床 Halcyon 装置以及用于比较的 TrueBeam 6MV FFF 上的测量结果评估结果的一致性。
估计归一化因子的解析方程中的五个参数的确定系数 R 为 0.997。Halcyon 代表性束流数据与医院束流数据之间的不平整度参数比较在 0.6%的范围内是一致的。与计算参数一致,Halcyon 的轮廓导致的峰值比 TrueBeam 不那么明显。
提供了 Varian Halcyon 装置产生的 6MV FFF 束流的归一化因子和相关拟合参数。