Pokhrel Damodar, Tackett Tanner, Stephen Joseph, Visak Justin, Amin-Zimmerman Falguni, McGregor Andrew, Strup Stephen E, St Clair William
Medical Physics Graduate Program, Department of Radiation Medicine, University of Kentucky, Lexington, KY, USA.
Lexington Clinic, University of Kentucky, Lexington, KY, USA.
J Appl Clin Med Phys. 2021 Jan;22(1):68-75. doi: 10.1002/acm2.13105. Epub 2020 Dec 19.
Cone beam CT-guided prostate stereotactic body radiotherapy (SBRT) treatment on the recently installed novel O-ring coplanar geometry Halcyon Linac with a single energy 6MV-flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a fast, safe, and feasible treatment modality for early stage low- and intermediate-risk prostate cancer patients. Following the RTOG-0938 compliance criteria and utilizing two-full arc geometry, VMAT prostate SBRT plans were generated for ten consecutive patients using advanced Acuros-based algorithm for heterogeneity corrections with Halcyon couch insert. Halcyon VMAT plans with the stacked and staggered multileaf collimators (MLC) produced highly conformal SBRT dose distributions to the prostate, lower intermediate dose spillage and similar dose to adjacent organs-at-risks (OARs) compared to SBRT-dedicated Truebeam VMAT plans. Due to lower monitor units per fraction and less MLC modulation through the target, the Halcyon VMAT plan can deliver prostate SBRT fractions in and overall treatment time of less than 10 minutes (for 36.25 Gy in five fractions), significantly improving patient compliance and clinic workflow. Pretreatment quality assurance results were similar to Truebeam VMAT plans. We have implemented Halcyon Linac for prostate SBRT treatment in our institution. We recommend that others use Halcyon for prostate SBRT treatments to expand the access of curative hypofractionated treatments to other clinics only equipped with a Halcyon Linac. Clinical follow-up results for patients who underwent prostate SBRT treatment on our Halcyon Linac is underway.
在最近安装的新型O型环共面几何结构的Halcyon直线加速器上,采用单能6MV-无均整器(FFF)束流和容积调强弧形治疗(VMAT)技术进行锥形束CT引导下的前列腺立体定向体部放疗(SBRT),对于早期低危和中危前列腺癌患者而言,是一种快速、安全且可行的治疗方式。遵循RTOG-0938的合规标准并采用双全弧几何结构,使用基于先进Acuros算法进行不均匀性校正并配备Halcyon治疗床插入件,为连续10例患者生成了VMAT前列腺SBRT计划。与专门用于SBRT的Truebeam VMAT计划相比,采用堆叠和交错多叶准直器(MLC)的Halcyon VMAT计划产生了高度适形的前列腺SBRT剂量分布,降低了中间剂量溢出,并且对相邻危及器官(OARs)的剂量相似。由于每分次的监测单位较低且通过靶区的MLC调制较少,Halcyon VMAT计划可以在不到10分钟的时间内完成前列腺SBRT分次治疗及整个治疗过程(5分次给予36.25Gy),显著提高了患者的依从性和临床工作流程。治疗前质量保证结果与Truebeam VMAT计划相似。我们机构已采用Halcyon直线加速器进行前列腺SBRT治疗。我们建议其他机构也使用Halcyon进行前列腺SBRT治疗,以便将根治性大分割治疗推广到其他仅配备Halcyon直线加速器的诊所。在我们的Halcyon直线加速器上接受前列腺SBRT治疗的患者的临床随访结果正在进行中。