Choi Min-Geon, Law Martin, Yoon Do-Kun, Tamura Mikoto, Matsumoto Kenji, Otsuka Masakazu, Kim Moo-Sub, Djeng Shih-Kien, Monzen Hajime, Suh Tae Suk
Department of Biomedical Engineering and Research Institute of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Proton Therapy Pte Ltd., 1 Biopolis Drive, Singapore, 138622, Singapore.
Radiat Oncol. 2020 Dec 7;15(1):273. doi: 10.1186/s13014-020-01709-x.
An O-ring gantry-type linear accelerator (LINAC) with a 6-MV flattening filter-free (FFF) photon beam, Halcyon, includes a reference beam that contains representative information such as the percent depth dose, profile and output factor for commissioning and quality assurance. However, because it does not provide information about the field size, we proposed a method to determine all field sizes according to all depths for radiation therapy using simplified sigmoidal curve fitting (SCF).
After mathematical definition of the SCF using four coefficients, the defined curves were fitted to both the reference data (RD) and the measured data (MD). For good agreement between the fitting curve and the profiles in each data set, the field sizes were determined by identifying the maximum point along the third derivative of the fitting curve. The curve fitting included the field sizes for beam profiles of 2 × 2, 4 × 4, 6 × 6, 8 × 8, 10 × 10, 20 × 20 and 28 × 28 cm as a function of depth (at 1.3, 5, 10 and 20 cm). The field size results from the RD were compared with the results from the MD using the same condition.
All fitting curves show goodness of fit, R, values that are greater than 0.99. The differences in field size between the RD and the MD were within the range of 0 to 0.2 cm. The smallest difference in the field sizes at a depth of 10 cm, which is a surface-to-axis distance, was reported.
Application of the SCF method has been proven to accurately capture the field size of the preconfigured RD and the measured FFF photon beam data for the Halcyon system. The current work can be useful for beam commissioning as a countercheck methodology to determine the field size from RD in the treatment planning system of a newly installed Halcyon system and for routine quality assurance to ascertain the correctness of field sizes for clinical use of the Halcyon system.
配备6兆伏无均整器(FFF)光子束的O型环龙门式直线加速器(LINAC),即Halcyon,包含一束参考光束,其中包含用于调试和质量保证的代表性信息,如百分深度剂量、剂量分布和输出因子。然而,由于它不提供射野大小的信息,我们提出了一种使用简化S形曲线拟合(SCF)来确定放射治疗中所有深度的所有射野大小的方法。
在使用四个系数对SCF进行数学定义后,将定义的曲线拟合到参考数据(RD)和测量数据(MD)上。为了使拟合曲线与每个数据集中的剂量分布良好吻合,通过确定拟合曲线三阶导数上的最大值点来确定射野大小。曲线拟合包括2×2、4×4、6×6、8×8、10×10、20×20和28×28厘米射野的剂量分布随深度(在1.3、5、10和20厘米处)的函数关系。将RD得到的射野大小结果与在相同条件下MD得到的结果进行比较。
所有拟合曲线的拟合优度R值均大于0.99。RD和MD之间的射野大小差异在0至0.2厘米范围内。报告了在作为表面到轴距离的10厘米深度处射野大小的最小差异。
已证明SCF方法的应用能够准确获取预配置RD的射野大小以及Halcyon系统测量的FFF光子束数据。当前工作对于束流调试作为一种在新安装的Halcyon系统的治疗计划系统中从RD确定射野大小的核对方法以及对于常规质量保证以确定Halcyon系统临床使用的射野大小的正确性可能是有用的。