Department of Gastrointestinal Surgery, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, 518020, China.
Department of Electronic Science and Technology, School of Physics and Technology, Wuhan University, Wuhan, 430072, China.
Angew Chem Int Ed Engl. 2020 Aug 10;59(33):13836-13843. doi: 10.1002/anie.202003672. Epub 2020 Jun 3.
The development of novel photosensitizing agents with aggregation-induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor-exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth. The hybridization of AIEgen and biological tumor-exocytosed exosomes was achieved for the first time, and combined with PDT approaches by normalizing the intratumoral vasculature as a means of reducing local tissue hypoxia. This work highlights a new approach to the design of AIEgen-based PDT systems and underscores the potential clinical value of AIEgens.
新型具有聚集诱导发光（AIE）特性的光敏剂的发展推动了光动力疗法（PDT）领域的重大进展。采用电穿孔法制备肿瘤外排外泌体/AIE 发光体（AIEgen）杂化纳米囊泡（DES），可促进高效肿瘤穿透。然后用地塞米松使肿瘤微环境（TME）中的血管功能正常化，以减少局部缺氧，从而显著提高 DES 纳米囊泡的 PDT 疗效，并使它们能够有效抑制肿瘤生长。首次实现了 AIEgen 和生物肿瘤外排外泌体的杂交，并结合 PDT 方法，通过使肿瘤内血管正常化来减少局部组织缺氧。这项工作强调了设计基于 AIEgen 的 PDT 系统的新方法，并突出了 AIEgen 的潜在临床价值。
