Chen Zhongxian, Liu Zeming, Zhou Yingguang, Rao Kexiang, Lin Jiaxin, Zhu Daoming, Ning Shipeng, Wang Hongbin
Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Mater Today Bio. 2024 Aug 24;28:101217. doi: 10.1016/j.mtbio.2024.101217. eCollection 2024 Oct.
Cold exposure therapy (CE), as an inexpensive method, has shown great potential in cancer therapy. Exploring the combined anti-tumor mechanism of CE and traditional therapies (such as photodynamic therapy (PDT)) is exciting and promising. Here, a bionic aggregation-induced emission photosensitizer system (named THL) is designed for combined CE to enhance anti-tumor immunotherapy. THL inherits the homologous targeting ability of tumor derived exosomes, promoting the enrichment of THL at the tumor site. Under external illumination, THL generates hydroxyl radicals and superoxide anions through type I PDT. In addition, mice are pretreated with cold exposure, which promotes THL mediated PDT and reactive oxygen species (ROS) generation by reducing the production of ATP and GSH in tumor tissue. This combination therapy increases production of ROS within the tumor, inhibits the growth of distant tumors, recurrent and rechallenged tumors and increases the number of cytotoxic CD8+T cells and memory T cells. Compared to PDT alone, combination therapy shows greater advantages in tumor immunotherapy. The combination therapy strategy provides new ideas for cancer immunotherapy.
冷暴露疗法（CE）作为一种低成本的方法，在癌症治疗中已显示出巨大潜力。探索CE与传统疗法（如光动力疗法（PDT））的联合抗肿瘤机制令人兴奋且前景广阔。在此，设计了一种仿生聚集诱导发光光敏剂系统（名为THL）用于联合CE以增强抗肿瘤免疫治疗。THL继承了肿瘤来源外泌体的同源靶向能力，促进THL在肿瘤部位富集。在外部光照下，THL通过I型PDT产生羟基自由基和超氧阴离子。此外，对小鼠进行冷暴露预处理，通过减少肿瘤组织中ATP和GSH的产生来促进THL介导的PDT和活性氧（ROS）生成。这种联合疗法增加了肿瘤内ROS的产生，抑制远处肿瘤、复发性肿瘤和再激发肿瘤的生长，并增加细胞毒性CD8 + T细胞和记忆T细胞的数量。与单独的PDT相比，联合疗法在肿瘤免疫治疗中显示出更大优势。该联合疗法策略为癌症免疫治疗提供了新思路。
