Julius L. Chambers Biomedical Biotechnology Research Institute (BBRI), North Carolina Central University, Durham, NC 27707, USA.
Bio-manufacturing Research Institute and Technology Enterprise (BRITE), North Carolina Central University, Durham, NC 27707, USA.
Cells. 2018 Dec 24;8(1):9. doi: 10.3390/cells8010009.
Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8) is a founding member of the TIPE family, which also includes TNFAIP8-like 1 (TIPE1), TNFAIP8-like 2 (TIPE2), and TNFAIP8-like 3 (TIPE3) proteins. Expression of TNFAIP8 is strongly associated with the development of various cancers including cancer of the prostate, liver, lung, breast, colon, esophagus, ovary, cervix, pancreas, and others. In human cancers, TNFAIP8 promotes cell proliferation, invasion, metastasis, drug resistance, autophagy, and tumorigenesis by inhibition of cell apoptosis. In order to better understand the molecular aspects, biological functions, and potential roles of TNFAIP8 in carcinogenesis, in this review, we focused on the expression, regulation, structural aspects, modifications/interactions, and oncogenic role of TNFAIP8 proteins in human cancers.
肿瘤坏死因子 (TNF)-α诱导蛋白 8 (TNFAIP8) 是 TIPE 家族的创始成员之一，该家族还包括 TNFAIP8 样蛋白 1 (TIPE1)、TNFAIP8 样蛋白 2 (TIPE2) 和 TNFAIP8 样蛋白 3 (TIPE3) 蛋白。TNFAIP8 的表达与包括前列腺癌、肝癌、肺癌、乳腺癌、结肠癌、食管癌、卵巢癌、宫颈癌、胰腺癌等在内的各种癌症的发展密切相关。在人类癌症中，TNFAIP8 通过抑制细胞凋亡促进细胞增殖、侵袭、转移、耐药性、自噬和肿瘤发生。为了更好地了解 TNFAIP8 在致癌作用中的分子方面、生物学功能和潜在作用，在本综述中，我们重点关注了 TNFAIP8 蛋白在人类癌症中的表达、调节、结构方面、修饰/相互作用和致癌作用。
