链脲佐菌素诱导的糖尿病小鼠中[具体亚种名称]的抗高血脂和抗氧化特性
Antihyperlipidemic and Antioxidative Properties of subsp. in Streptozotocin-Induced Diabetic Mice.
作者信息
Hosseini Seyran, Nili-Ahmadabadi Amir, Nachvak Seyed Mostafa, Dastan Dara, Moradi Shima, Abdollahzad Hadi, Mostafai Roghayeh
机构信息
Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Diabetes Metab Syndr Obes. 2020 Apr 20;13:1231-1236. doi: 10.2147/DMSO.S250417. eCollection 2020.
Abstract
INTRODUCTION
subsp. is an important food source and a well-known medicinal plant in the Zagros Mountains of Iran. The present study aimed to investigate the effect of extract and essential oil in streptozotocin-induced diabetic mice.
MATERIALS AND METHODS
Different doses of hydroalcoholic extract and essential oil of subsp. (50, 100, and 200 mg/kg) were given to streptozotocin-induced diabetic mice in separate groups for three weeks. At the end of treatment, blood samples were collected; then, oxidative stress markers, TNF-α, and lipid profile were determined in its serum samples.
RESULTS
Our findings showed that the administration of extract for three consecutive weeks significantly improved the lipid profile, oxidative stress, and inflammation process by reducing lipid peroxidation and increasing total antioxidant capacity.
CONCLUSION
This study showed that subsp. has antioxidant and blood lipid-lowering effects that can be used as a supplement to improve diabetes complications.
摘要
引言
[植物名称]亚种是伊朗扎格罗斯山脉一种重要的食物来源和著名的药用植物。本研究旨在探讨[植物名称]亚种提取物和精油对链脲佐菌素诱导的糖尿病小鼠的影响。
材料与方法
将不同剂量（50、100和200mg/kg）的[植物名称]亚种水醇提取物和精油分别给予链脲佐菌素诱导的糖尿病小鼠组，持续三周。治疗结束时，采集血样；然后，测定其血清样本中的氧化应激标志物、肿瘤坏死因子-α和血脂谱。
结果
我们的研究结果表明，连续三周给予[植物名称]亚种提取物可通过降低脂质过氧化和提高总抗氧化能力，显著改善血脂谱、氧化应激和炎症过程。
结论
本研究表明，[植物名称]亚种具有抗氧化和降血脂作用，可作为改善糖尿病并发症的补充剂。
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