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刚果民主共和国金沙萨转至社区药物补充中心的HIV患者的病毒抑制情况及持续留存率

Retention and sustained viral suppression in HIV patients transferred to community refill centres in Kinshasa, DRC.

作者信息

Moudachirou R, Van Cutsem G, Chuy R I, Tweya H, Senkoro M, Mabhala M, Zolfo M

机构信息

Projet SIDA, Médecins Sans Frontières, Operational Centre of Brussels, Kinshasa, Democratic Republic of Congo.

Southern Africa Medical Unit, Médecins Sans Frontières, Cape Town, South Africa.

出版信息

Public Health Action. 2020 Mar 21;10(1):33-37. doi: 10.5588/pha.19.0067.

Abstract

SETTING

In 2010, Médecins Sans Frontières set up decentralised community antiretroviral therapy (ART) refill centres ("", PODI) for the follow-up of stable human immunodeficiency virus (HIV) patients.

OBJECTIVE

To assess retention in care and sustained viral suppression after transfer to three main PODI in Kinshasa, Democratic Republic of Congo (DRC) (PODI Barumbu/Central, PODI Binza Ozone/West and PODI Masina I/East).

DESIGN

Retrospective cohort study using routine programme data for adult HIV patients transferred from Kabinda Hospital to PODIs between January 2015 and June 2017.

RESULTS

A total of 337 patients were transferred to PODIs: 306 (91%) were on ART for at least 12 months; 118 (39%) had a routine "12-month" viral load (VL) done, 93% ( 110) of whom had a suppressed VL <1000 copies/ml. Median time from enrolment into PODI to 12-month routine VL was 14.6 months (IQR 12.2-20.8). Kaplan-Meier estimates of retention in care at 6, 12 and 18 months after enrolment into PODIs were respectively 96%, 92% and 88%.

CONCLUSION

Retention in care and viral suppression among patients in PODI with VL results were better than patients in clinic care and national outcomes.

摘要

背景

2010年,无国界医生组织设立了分散式社区抗逆转录病毒疗法(ART)补充中心(“PODI”),用于对稳定的人类免疫缺陷病毒(HIV)患者进行随访。

目的

评估转至刚果民主共和国(DRC)金沙萨三个主要PODI(PODI Barumbu/中心、PODI Binza Ozone/西部和PODI Masina I/东部)后患者的治疗依从性和持续病毒抑制情况。

设计

一项回顾性队列研究,使用2015年1月至2017年6月间从卡宾达医院转至PODI的成年HIV患者的常规项目数据。

结果

共有337名患者转至PODI:306名(91%)接受抗逆转录病毒治疗至少12个月;118名(39%)进行了常规的“12个月”病毒载量(VL)检测,其中93%(110名)的病毒载量被抑制在<1000拷贝/毫升。从登记进入PODI到进行12个月常规病毒载量检测的中位时间为14.6个月(四分位间距12.2 - 20.8)。登记进入PODI后6个月、12个月和18个月的治疗依从性的Kaplan-Meier估计值分别为96%、92%和88%。

结论

有病毒载量检测结果的PODI患者的治疗依从性和病毒抑制情况优于门诊治疗患者和国家层面的结果。

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