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Virological and care outcomes of community ART distribution: Experience with the PODI+ model in Kinshasa, Democratic Republic of the Congo.

作者信息

Gill Michelle M, Bakebua Winnie, Ditekemena John, Gbomosa Cady Nyombe, Tshishi Dieudonné, Loando Aimé, Giri Abhigya, Ngantsui Roger Beni, Hoffman Heather J

机构信息

Elizabeth Glaser Pediatric AIDS Foundation, Washington, District of Columbia, United States of America.

Elizabeth Glaser Pediatric AIDS Foundation, Kinshasa, Democratic Republic of the Congo.

出版信息

PLOS Glob Public Health. 2024 Jan 31;4(1):e0002343. doi: 10.1371/journal.pgph.0002343. eCollection 2024.


DOI:10.1371/journal.pgph.0002343
PMID:38295044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10830041/
Abstract

INTRODUCTION: Differentiated service delivery models for HIV treatment can minimize unnecessary burdens on health systems and promote efficient delivery of antiretroviral therapy (ART). Under the PODI+ (poste de distribution communautaire) model, ART multi-month dispensation (MMD) was provided by lay workers (peers) in communities. We compared outcomes among clinically stable adults living with HIV receiving MMD via PODI+ or health facility (HF). METHODS: Clients receiving MMD at nine HFs and two PODI+ sites in Kinshasa were followed prospectively for one year (2018-2020). Medication possession ratio (MPR) was measured as proportion of total days with medication during the study through record abstraction at 3-month intervals. Viral load was assessed at enrollment and 12 months. We compared MPR and viral load suppression by arm and examined associations and potential confounders using unadjusted and adjusted odds ratios (AOR). Likert-style client satisfaction was collected during 12-month interviews and described by arm. RESULTS: Odds of maintaining viral load suppression at 12 months for PODI+ participants were two times that for HF participants. In adjusted models, PODI+ participants had 1.89 times the odds of being suppressed at 12 months compared to HF participants (95% CI: 1.10, 3.27). No significant differences in MPR were found between groups (OR: 0.86, 0.38-1.99). Older participants had significantly higher odds of MPR (AOR: 1.02, 95% CI: 1.01, 1.03) and viral suppression (AOR: 1.03, 95% CI: 1.00, 1.07). Satisfaction with services was ≥87% overall, but PODI+ participants rated time spent at site, provider attributes and other care aspects more favorably. CONCLUSIONS: Participants receiving MMD via peer-run community distribution points had similar MPR, but better virological outcomes and greater satisfaction with care than clinically similar participants receiving MMD through facilities. PODI+ could be a useful model for expansion to serve larger clinic populations from overburdened health facilities, particularly as policy shifts towards more inclusive MMD eligibility requirements.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48c1/10830041/135383b4833d/pgph.0002343.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48c1/10830041/b214d680797a/pgph.0002343.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48c1/10830041/135383b4833d/pgph.0002343.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48c1/10830041/b214d680797a/pgph.0002343.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48c1/10830041/135383b4833d/pgph.0002343.g002.jpg

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[1]
Virological and care outcomes of community ART distribution: Experience with the PODI+ model in Kinshasa, Democratic Republic of the Congo.

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[2]
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本文引用的文献

[1]
Liberia adherence and loss-to-follow-up in HIV and AIDS care and treatment: A retrospective cohort of adolescents and adults from 2016-2019.

PLOS Glob Public Health. 2022-3-23

[2]
Rates of viral suppression in a cohort of people with stable HIV from two community models of ART delivery versus facility-based HIV care in Lusaka, Zambia: a cluster-randomised, non-inferiority trial nested in the HPTN 071 (PopART) trial.

Lancet HIV. 2022-1

[3]
Changes in HIV treatment differentiated care uptake during the COVID-19 pandemic in Zambia: interrupted time series analysis.

J Int AIDS Soc. 2021-10

[4]
Community-based differentiated service delivery models incorporating multi-month dispensing of antiretroviral treatment for newly stable people living with HIV receiving single annual clinical visits: a pooled analysis of two cluster-randomized trials in southern Africa.

J Int AIDS Soc. 2021-10

[5]
Differentiated service delivery models among PLHIV in Akwa Ibom and Cross River States, Nigeria during the COVID-19 pandemic: descriptive analysis of programmatic data.

J Int AIDS Soc. 2021-10

[6]
The impact of COVID-19 on multi-month dispensing (MMD) policies for antiretroviral therapy (ART) and MMD uptake in 21 PEPFAR-supported countries: a multi-country analysis.

J Int AIDS Soc. 2021-10

[7]
Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomized clinical trial.

PLoS Med. 2021-10

[8]
How community ART delivery may improve HIV treatment outcomes: Qualitative inquiry into mechanisms of effect in a randomized trial of community-based ART initiation, monitoring and re-supply (DO ART) in South Africa and Uganda.

J Int AIDS Soc. 2021-10

[9]
Expanding access to HIV services during the COVID-19 pandemic-Nigeria, 2020.

AIDS Res Ther. 2021-9-19

[10]
Out-of-Facility Multimonth Dispensing of Antiretroviral Treatment: A Pooled Analysis Using Individual Patient Data From Cluster-Randomized Trials in Southern Africa.

J Acquir Immune Defic Syndr. 2021-12-15

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