Dumont A E
Department of Surgery, New York University Medical Center, New York.
Lymphology. 1988 Dec;21(4):234-8.
The accumulation of iron in the lymph nodes of trypan blue treated rats was examined as a possible experimental counterpart of the lymph node siderosis which occurs in patients with Hodgkin's disease. Lymph nodes removed from the hilus of the liver, retrosternal area, axilla and root of the small bowel mesentery were examined histologically for iron in rats receiving 6-20 subcutaneous injections of trypan blue at biweekly intervals and in control rats. An increase in erythrophagocytosis accompanied by a progressive increase in the amount of stainable iron was found in the RE cells of nodes located in the lymphatic outflow tract of the liver. As in patients with Hodgkin's disease, an increase in erythrophagocytosis together with the prolonged retention of iron by RE cells appears to account for the accumulation of iron in the lymph nodes of trypan blue treated rats.
研究了经锥虫蓝处理的大鼠淋巴结中铁的蓄积情况，将其作为霍奇金病患者发生的淋巴结铁质沉着症可能的实验对应情况。对接受每两周皮下注射6 - 20次锥虫蓝的大鼠以及对照大鼠，取肝脏门部、胸骨后区域、腋窝和小肠系膜根部的淋巴结进行组织学检查，以检测铁含量。在位于肝脏淋巴引流道的淋巴结的网状内皮细胞中，发现吞噬红细胞作用增加，同时可染色铁的量逐渐增加。与霍奇金病患者一样，吞噬红细胞作用增加以及网状内皮细胞对铁的长时间潴留似乎是锥虫蓝处理的大鼠淋巴结中铁蓄积的原因。
