Rabatić S, Sabioncello A, Dekaris D, Kardum I
Institute of Immunology and Clinical Hospital Dr. O. Novosel, University of Zagreb, Yugoslavia.
Mech Ageing Dev. 1988 Nov 30;45(3):223-9. doi: 10.1016/0047-6374(88)90004-8.
Ingestion, digestion and antibody-dependent cell-mediated cytotoxicity (ADCC) of opsonized sheep red blood cells (SRBC), as effector functions of peripheral blood phagocytes, were studied in newborns, children, mature and aged adults. All tested functions changed non-synchronously during the lifetime. The ingestion was maximal in newborns, digestion in children and ADCC in mature adults. The ingestion was minimal in aged, but digestion was minimal both in newborns and aged. Such changes of phagocytes' functions could possibly contribute to differences in immune reactions of the age-groups studied. The study indicates the need for establishing age-adjusted normal values for major granulocyte and monocyte effector functions.
作为外周血吞噬细胞的效应功能，对调理的绵羊红细胞（SRBC）的摄取、消化以及抗体依赖性细胞介导的细胞毒性（ADCC）在新生儿、儿童、成年人及老年人中进行了研究。所有测试功能在一生中呈非同步变化。摄取功能在新生儿中最强，消化功能在儿童中最强，ADCC在成年人中最强。摄取功能在老年人中最弱，但消化功能在新生儿和老年人中均最弱。吞噬细胞功能的这种变化可能导致所研究年龄组免疫反应的差异。该研究表明需要为主要粒细胞和单核细胞效应功能建立年龄校正后的正常值。
