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人初乳吞噬细胞的抗体依赖性细胞毒性

Antibody dependent cytotoxicity of human colostrum phagocytes.

作者信息

Mandyla H, Xanthou M, Maravelias C, Baum D, Matsaniotis N

出版信息

Pediatr Res. 1982 Dec;16(12):995-9. doi: 10.1203/00006450-198212000-00004.

DOI:10.1203/00006450-198212000-00004
PMID:7155677
Abstract

Monocytes and polymorphonuclear neutrophils of human colostrum were identified using cytochemical staining procedures. The ability of colostral phagocytes to function in antibody dependent cellular cytotoxicity was found to be satisfactory at high effector/target cells ratio (20:1) Colostral monocytes showed a diminished cytotoxicity when compared to monocytes of adult or neonatal peripheral blood at low effector/target cells ratio (1:1). This could be due to the extensive fat ingestion by these cells or other inhibitory factors found in colostrum.

摘要

通过细胞化学染色程序鉴定了人初乳中的单核细胞和多形核中性粒细胞。发现在高效应细胞/靶细胞比例(20:1)下,初乳吞噬细胞在抗体依赖性细胞毒性中发挥作用的能力令人满意。在低效应细胞/靶细胞比例(1:1)下,与成人或新生儿外周血中的单核细胞相比,初乳单核细胞的细胞毒性降低。这可能是由于这些细胞大量摄取脂肪或初乳中存在其他抑制因子所致。

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1
Antibody dependent cytotoxicity of human colostrum phagocytes.人初乳吞噬细胞的抗体依赖性细胞毒性
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Compensation of preliminary blood phagocyte immaturity in the newborn calf.新生犊牛初期血液吞噬细胞不成熟的补偿作用。
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引用本文的文献

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Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers.人乳:从食物到婴儿和母亲疾病保护的主动免疫反应。
Front Immunol. 2022 Apr 5;13:849012. doi: 10.3389/fimmu.2022.849012. eCollection 2022.
2
Impaired production and lack of secretion of interleukin 1 by human breast milk macrophages.人母乳巨噬细胞白细胞介素1产生受损及分泌缺乏。
Clin Exp Immunol. 1988 Mar;71(3):493-6.
3
In vivo distribution of human milk leucocytes after ingestion by newborn baboons.新生狒狒摄入人乳后其中白细胞的体内分布情况。
Arch Dis Child. 1989 Jul;64(7 Spec No):930-3. doi: 10.1136/adc.64.7_spec_no.930.