Somova L, Kirjakov A, Dashev G, Doncheva M, Vassileva M, Tchoneva G, Valkova S
Institute of Endocrinology and Gerontology, Bulgarian Medical Academy, Sofia.
Methods Find Exp Clin Pharmacol. 1988 Dec;10(12):751-4.
Lipid peroxide levels and plasma lipids were studied in plasma lipoprotein fractions of streptozotocin diabetic rats, spontaneous hypertensive rats (SHR) + diabetes, and in myocardial infarction rats (MIR) + diabetes. The duration of diabetes in all experimental groups was 2.5 months. We found a tendency of elevation of cholesterol in VLDL and fall in HDL2 but the differences were not significant. Total plasma triglycerides were increased in the three diabetic groups, and the increase was due to LDL fraction but again the differences were not significant. The lipid peroxide (LP) level in total plasma showed a significant increase in the three diabetic groups: in Wistar diabetic rats LP increased 3 times, in MIR + diabetes 3.5 times, and in SHR + diabetes 5 times. The increase of LP in the three diabetic groups was due to LDL with good correlation (r = 0.60) between LP and triglycerides in LDL of the three diabetic groups. The results are in agreement with the concept of the importance of lipoprotein fraction changes: increased cholesterol, triglycerides and lipid peroxides in atherogenic (VLDL and LDL) fractions, and decreased levels in antiatherogenic (HDL, HDL2) fractions in diabetes mellitus.
研究了链脲佐菌素诱导的糖尿病大鼠、自发性高血压大鼠（SHR）合并糖尿病大鼠以及心肌梗死大鼠（MIR）合并糖尿病大鼠血浆脂蛋白组分中的脂质过氧化物水平和血脂。所有实验组的糖尿病病程均为2.5个月。我们发现VLDL中胆固醇有升高趋势，HDL2有下降趋势，但差异不显著。三个糖尿病组的血浆总甘油三酯均升高，且升高是由于LDL组分，但差异同样不显著。三个糖尿病组的血浆总脂质过氧化物（LP）水平均显著升高：在Wistar糖尿病大鼠中LP升高3倍，在MIR合并糖尿病大鼠中升高3.5倍，在SHR合并糖尿病大鼠中升高5倍。三个糖尿病组中LP的升高归因于LDL，且三个糖尿病组中LP与LDL中的甘油三酯具有良好的相关性（r = 0.60）。这些结果与脂蛋白组分变化的重要性这一概念相符：在糖尿病中，致动脉粥样硬化（VLDL和LDL）组分中的胆固醇、甘油三酯和脂质过氧化物增加，而抗动脉粥样硬化（HDL、HDL2）组分中的水平降低。
