Fibroblast Growth Factor Inhibitors in Lung Fibrosis: Friends or Foes?
作者信息
Guzy Robert
机构信息
Department of Medicine, Section of Pulmonary and Critical Care Medicine The University of Chicago Chicago, Illinois.
出版信息
Am J Respir Cell Mol Biol. 2020 Sep;63(3):273-274. doi: 10.1165/rcmb.2020-0156ED.
Abstract
摘要
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本文引用的文献
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Am J Respir Cell Mol Biol. 2020 Sep;63(3):317-326. doi: 10.1165/rcmb.2019-0090OC.
2
FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury.成纤维细胞生长因子受体 2（FGFR2）在博来霉素诱导的肺损伤后对 AEC2 的稳态和存活是必需的。
Am J Respir Cell Mol Biol. 2020 May;62(5):608-621. doi: 10.1165/rcmb.2019-0079OC.
3
FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury.FGF10-FGFR2B 信号通过支气管上皮干细胞产生基底细胞，并在肺损伤后驱动肺泡上皮再生。
Stem Cell Reports. 2019 May 14;12(5):1041-1055. doi: 10.1016/j.stemcr.2019.04.003. Epub 2019 May 2.
4
Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.成纤维细胞生长因子 2 可减少博来霉素诱导的肺纤维化，并抑制成纤维细胞胶原产生和肌成纤维细胞分化。
J Pathol. 2018 Sep;246(1):54-66. doi: 10.1002/path.5106. Epub 2018 Jul 5.
5
Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling.肺纤维化需要细胞自主的间充质成纤维细胞生长因子（FGF）信号传导。
J Biol Chem. 2017 Jun 23;292(25):10364-10378. doi: 10.1074/jbc.M117.791764. Epub 2017 May 9.
6
Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.在支气管肺发育不良的小鼠模型中，成纤维细胞生长因子10（Fgf10）缺乏是致死的原因。
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