Department of Interventional Ultrasound Medicine, China-Japan Friendship Hospital, Beijing, China.
Int J Hyperthermia. 2020;37(1):450-455. doi: 10.1080/02656736.2020.1759829.
To evaluate the efficacy and safety of microwave ablation (MWA) for cervical metastatic lymph nodes (LNs) post resection of papillary thyroid cancer (PTC). From November 2015 to November 2018, 14 patients with 38 cervical metastatic LNs treated by MWA were included in this retrospective study. Wilcoxon signed rank test was used to compare the changes of LN and serum thyroglobulin levels pre- and post-ablation. The technical success rate in this study was 100% (38/38). The mean follow-up time was 23.6 ± 9.3 months. On pre-ablation contrast-enhanced ultrasound, 25 LNs showed high-enhancement, 8 LNs showed iso-enhancement, and 5 LNs showed low-enhancement. The median largest diameter of LNs at pre-ablation and 3, 6, 9, 12, 18, 24, and 36 months post-ablation was 11.5 mm and 9.5, 9.0, 8.0, 8.0, 8.0, 7.0, and 6.0 mm, respectively. The median volume of LNs at pre-ablation and 3, 6, 9, 12, 18, 24, and 36 months post-ablation were 251.2 mm and 206.7, 167.2, 166.2, 155.7, 153.9, 153.9, and 113.1 mm, respectively. The largest diameter and the volume of the cervical metastatic LNs at the last post-ablation was significantly smaller than the pre-ablation level ( = .0016; = .0018). Serum Tg level at the last post-ablation (median 1.25 ng/mL) was significantly lower than the pre-ablation level (median 8.35 ng/mL) ( = .001). There were no complications. MWA is a safe and effective novel treatment option for cervical metastatic LN that emerge post resection of PTC.
评估微波消融（MWA）治疗甲状腺乳头状癌（PTC）术后颈转移性淋巴结（LNs）的疗效和安全性。从 2015 年 11 月至 2018 年 11 月，我们回顾性研究了 14 例 38 个颈转移性 LNs 接受 MWA 治疗的患者。采用 Wilcoxon 符号秩检验比较消融前后 LN 和血清甲状腺球蛋白水平的变化。本研究的技术成功率为 100%（38/38）。平均随访时间为 23.6±9.3 个月。在消融前的增强超声检查中，25 个 LNs 呈高增强，8 个 LNs 呈等增强，5 个 LNs 呈低增强。消融前 LNs 的最大直径中位数为 11.5mm，消融后 3、6、9、12、18、24 和 36 个月时的中位数分别为 9.5、9.0、8.0、8.0、8.0、7.0 和 6.0mm。消融前 LNs 的体积中位数为 251.2mm，消融后 3、6、9、12、18、24 和 36 个月时的中位数分别为 206.7、167.2、166.2、155.7、153.9、153.9 和 113.1mm。最后一次消融后 LNs 的最大直径和体积明显小于消融前（ = .0016； = .0018）。最后一次消融后血清 Tg 水平（中位数 1.25ng/mL）明显低于消融前（中位数 8.35ng/mL）（ = .001）。无并发症发生。MWA 是治疗 PTC 术后颈转移性 LNs 的一种安全有效的新方法。
