Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA.
Dev Cell. 2020 May 4;53(3):257-258. doi: 10.1016/j.devcel.2020.04.014.
Topographic map development requires precise coordination between navigating axons and their targets in a dynamic environment. In this issue of Developmental Cell, Isabella et al. describe a mechanism in which a changing gradient of the morphogen retinoic acid regulates the expression of guidance factors to shape topographic axon targeting.
地形地图的发展需要在动态环境中导航轴突与其靶标之间进行精确的协调。在本期《发育细胞》中,Isabella 等人描述了一种机制,即形态发生素视黄酸的梯度变化调节导向因子的表达,从而形成地形轴突靶向。