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迷走神经拓扑图:游走于渐变之间。

Vagus Topographic Map: Wandering through a gRAdient.

机构信息

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA.

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA.

出版信息

Dev Cell. 2020 May 4;53(3):257-258. doi: 10.1016/j.devcel.2020.04.014.

Abstract

Topographic map development requires precise coordination between navigating axons and their targets in a dynamic environment. In this issue of Developmental Cell, Isabella et al. describe a mechanism in which a changing gradient of the morphogen retinoic acid regulates the expression of guidance factors to shape topographic axon targeting.

摘要

地形地图的发展需要在动态环境中导航轴突与其靶标之间进行精确的协调。在本期《发育细胞》中,Isabella 等人描述了一种机制,即形态发生素视黄酸的梯度变化调节导向因子的表达,从而形成地形轴突靶向。

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Vagus Topographic Map: Wandering through a gRAdient.迷走神经拓扑图:游走于渐变之间。
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本文引用的文献

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Developmental mechanisms of topographic map formation and alignment.地形图形成和对准的发育机制。
Annu Rev Neurosci. 2013 Jul 8;36:51-77. doi: 10.1146/annurev-neuro-062012-170341. Epub 2013 Apr 29.
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Development of continuous and discrete neural maps.连续和离散神经图谱的发育
Neuron. 2007 Oct 25;56(2):284-300. doi: 10.1016/j.neuron.2007.10.014.

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