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异常体重指数对骨科创伤患者的影响:一项系统评价和荟萃分析。

The Effect of an Abnormal BMI on Orthopaedic Trauma Patients: A Systematic Review and Meta-Analysis.

作者信息

Kinder Florence, Giannoudis Peter V, Boddice Tim, Howard Anthony

机构信息

Undergraduate Department, School of Medicine, Leeds University, Leeds LS2 9JT, UK.

Leeds Orthopaedic Trauma Sciences, LGI, University of Leeds, Leeds LS2 9JT, UK.

出版信息

J Clin Med. 2020 May 1;9(5):1302. doi: 10.3390/jcm9051302.

Abstract

AIMS

The aim of this systemic review is to identify the complications that arise in operating on orthopaedic trauma patients with an abnormal body mass index (BMI).

MATERIALS AND METHODS

Systematic literature search using a combination of MESH subject headings and free text searching of Medline, Embase, SCOPUS and Cochrane databases in August 2019. Any orthopaedic injury requiring surgery was included. Papers were reviewed and quality assessed by two independent reviewers to select for inclusion. Where sufficiently homogenous, meta-analysis was performed.

RESULTS

A total of 26 articles (379,333 patients) were selected for inclusion. All complications were more common in those with a high BMI (>30). The odds ratio (OR) for high BMI patients sustaining post-operative complication of any type was 2.32 with a 23% overall complication rate in the BMI > 30 group, vs. 14% in the normal BMI group ( < 0.05). The OR for mortality was 3.5. The OR for infection was 2.28. The OR for non-union in tibial fractures was 2.57. Thrombotic events were also more likely in the obese group. Low BMI (<18.5) was associated with a higher risk of cardiac complications than either those with a normal or high BMI (OR 1.56).

CONCLUSION

Almost all complications are more common in trauma patients with a raised BMI. This should be made clear during the consent process, and strategies developed to reduce these risks where possible. Unlike in elective surgery, BMI is a non-modifiable risk factor in the trauma context, but an awareness of the complications should inform clinicians and patients alike. Underweight patients have a higher risk of developing cardiac complications than either high or normal BMI patient groups, but as few studies exist, further research into this group is recommended.

摘要

目的

本系统评价旨在确定对体重指数(BMI)异常的骨科创伤患者进行手术时出现的并发症。

材料与方法

2019年8月,使用医学主题词(MESH)和自由文本搜索相结合的方式,对Medline、Embase、SCOPUS和Cochrane数据库进行系统文献检索。纳入任何需要手术的骨科损伤。由两名独立评审员对论文进行评审和质量评估以选择纳入。在足够同质的情况下,进行荟萃分析。

结果

共纳入26篇文章(379333例患者)。所有并发症在BMI较高(>30)的患者中更为常见。BMI>30组中,BMI高的患者发生任何类型术后并发症的比值比(OR)为2.32,总体并发症发生率为23%,而正常BMI组(<30)为14%(P<0.05)。死亡的OR为3.5。感染的OR为2.28。胫骨骨折不愈合的OR为2.57。肥胖组发生血栓事件的可能性也更高。低BMI(<18.5)与心脏并发症风险高于正常或高BMI患者相关(OR 1.56)。

结论

几乎所有并发症在BMI升高的创伤患者中更为常见。这在知情同意过程中应予以明确,并尽可能制定降低这些风险的策略。与择期手术不同,在创伤情况下BMI是不可改变的风险因素,但对并发症的认识应告知临床医生和患者。体重过轻的患者发生心脏并发症的风险高于高BMI或正常BMI患者组,但由于相关研究较少,建议对该组进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb2c/7290578/146a3854f05f/jcm-09-01302-g001.jpg

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