Bae Seongryu, Harada Kenji, Lee Sangyoon, Harada Kazuhiro, Makino Keitaro, Chiba Ippei, Park Hyuntae, Shimada Hiroyuki
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Graduate School of Human Development and Environment, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan.
J Clin Med. 2020 May 2;9(5):1312. doi: 10.3390/jcm9051312.
The aim of this study was to examine cortical thickness changes associated with a multicomponent exercise intervention combining physical exercise and cognitive training in older adults with cognitive decline. This study involved a secondary analysis of neuroimaging data from a randomized controlled trial with 280 older adults having cognitive decline who were randomly assigned to either a multicomponent exercise group ( = 140) that attended weekly 90-minute exercise and cognitive training sessions or a health education control group ( = 140). The cortical thickness and cognitive performance were assessed at the baseline and at trial completion (10 months). The cortical thickness in the frontal and temporal regions was determined using FreeSurfer software. Cognitive performance was evaluated using the Gerontology-Functional Assessment Tool (NCGG-FAT). The cortical thickness significantly increased in the middle temporal ( < 0.001) and temporal pole ( < 0.001) in the multicomponent exercise group compared with the control group. Cortical thickness changes were significantly associated with change in trail making test (TMT)-A, TMT-B, and story memory after a 10-month multicomponent exercise intervention. This study suggests that multicomponent exercise programs combining physical exercise and cognitive training have important implications for brain health, especially in providing protection from age-related cortical thinning.
本研究的目的是在认知功能减退的老年人中，研究与体育锻炼和认知训练相结合的多组分运动干预相关的皮质厚度变化。本研究涉及对一项随机对照试验的神经影像数据进行二次分析，该试验有280名认知功能减退的老年人，他们被随机分配到多组分运动组（n = 140），该组每周参加90分钟的运动和认知训练课程，或健康教育对照组（n = 140）。在基线和试验结束时（10个月）评估皮质厚度和认知表现。使用FreeSurfer软件确定额叶和颞叶区域的皮质厚度。使用老年医学功能评估工具（NCGG-FAT）评估认知表现。与对照组相比，多组分运动组中颞叶中部（p < 0.001）和颞极（p < 0.001）的皮质厚度显著增加。在进行10个月的多组分运动干预后，皮质厚度变化与连线测验（TMT）-A、TMT-B和故事记忆的变化显著相关。本研究表明，体育锻炼和认知训练相结合的多组分运动计划对大脑健康具有重要意义，尤其是在预防与年龄相关的皮质变薄方面。
