Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Department of Physiology, Kazan State Medical University, Butlerova 49, R-420012 Kazan, Russia.
Int J Mol Sci. 2020 May 2;21(9):3226. doi: 10.3390/ijms21093226.
Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer's disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed.
心房颤动（AF）是最常见的心律失常形式之一，会增加中风的风险，而中风反过来又与认知能力下降密切相关。大多数痴呆病例是由发病机制尚不清楚的阿尔茨海默病（AD）引起的。虽然确切的机制尚不清楚，但炎症过程和感染因子在 AD 和 AF 中的作用最近已经被牵涉到，这表明这些疾病之间存在共同的联系。在这里，我们介绍了心律失常和记忆力丧失的主要共同途径。还讨论了重叠的预测生物标志物和新兴的联合药物治疗方法。
