Varrias Dimitrios, Saralidze Tinatin, Borkowski Pawel, Pargaonkar Sumant, Spanos Michail, Bazoukis George, Kokkinidis Damianos
Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Biomolecules. 2024 Apr 8;14(4):455. doi: 10.3390/biom14040455.
Numerous longitudinal studies suggest a strong association between cardiovascular risk factors and cognitive impairment. Individuals with atrial fibrillation are at higher risk of dementia and cognitive dysfunction, as atrial fibrillation increases the risk of cerebral hypoperfusion, inflammation, and stroke. The lack of comprehensive understanding of the observed association and the complex relationship between these two diseases makes it very hard to provide robust guidelines on therapeutic indications. With this review, we attempt to shed some light on how atrial fibrillation is related to dementia, what we know regarding preventive interventions, and how we could move forward in managing those very frequently overlapping conditions.
众多纵向研究表明心血管危险因素与认知障碍之间存在密切关联。房颤患者患痴呆和认知功能障碍的风险更高，因为房颤会增加脑灌注不足、炎症和中风的风险。对所观察到的这种关联以及这两种疾病之间复杂关系缺乏全面了解，使得很难就治疗指征提供强有力的指导方针。通过本综述，我们试图阐明房颤与痴呆的关系、我们对预防性干预措施的了解，以及我们在管理这些经常重叠的病症方面如何取得进展。
