Institut für Molekulare Mikrobiologie und Biotechnologie, Westfälische Wilhelms Universität, Corrensstr. 3, 48149 Münster, Germany.
School of Civil and Environmental Engineering, Yonsei University, Seoul 03722, Republic of Korea.
Bioresour Technol. 2020 Aug;309:123400. doi: 10.1016/j.biortech.2020.123400. Epub 2020 Apr 18.
The developing approaches in the recovery of resources from biowastes for the production of renewable value-added products and fuels, using microbial cultures as bio-catalyst have now became promising aspect. In the path of anaerobic digestion, the microorganisms are assisting transformation of a complex organic feedstock/waste to biomass and biogas. This potentiality consequently leads to the production of intermediate precursors of renewable value-added products. Particularly, a set of anaerobic pathways in the fermentation process, yields small-chain fatty acids (SCFA), and medium-chain fatty acids (MCFA) via chain elongation pathways from waste valorization and CO fixation. This review focuses on the production of SCFA and MCFA from CO, synthetic substrates and waste materials. Moreover, the review introduces the metabolic engineering of Escherichia coli and Saccharomyces cerevisiae for SCFAs/MCFAs production. Furtherly, it concludes that future critical research might target progress of this promising approach as a valorization of complex organic wastes.
利用微生物培养物作为生物催化剂，从生物废物中回收资源以生产可再生增值产品和燃料的开发方法现在已经成为一个很有前途的方面。在厌氧消化途径中，微生物有助于将复杂的有机原料/废物转化为生物质和沼气。这种潜力进而导致了可再生增值产品的中间前体的生产。特别是，发酵过程中的一套厌氧途径通过废物增值和 CO 固定的链延长途径产生短链脂肪酸 (SCFA) 和中链脂肪酸 (MCFA)。本综述重点介绍了从 CO、合成底物和废物材料生产 SCFA 和 MCFA。此外，该综述还介绍了大肠杆菌和酿酒酵母的代谢工程，以生产 SCFA/MCFA。此外，它得出结论，未来的关键研究可能以这种有前途的方法作为复杂有机废物的增值为目标。
